NGS REPORTS
EXPLAINED
An NGS report is a lot of information in a format built for specialists. Knowing where the clinically significant content is -- and what questions to bring to the follow-up -- is what makes the document useful.
What Each Section of the NGS Report Contains
Underneath the different templates from different laboratories, the same categories of information appear. Knowing which section is which makes navigation straightforward.
Clinical Summary / Actionable Findings -- Read First
Usually at the front. Approved therapies matched to detected alterations. Clinical trials associated with the molecular profile. Immunotherapy biomarker results. If something in this report is going to change treatment, it appears here.
Detected Alterations -- The Full List
Every genetic change the test identified. Includes gene name, alteration type (substitution, deletion, amplification, fusion), and variant allele frequency. Not all of these are clinically significant. Most are context, not action.
Tier Classification -- Evidence Strength
Tier I: approved therapy exists or major guideline inclusion. Tier II: potential clinical relevance, emerging or investigational evidence. Tier III: variant of uncertain significance. Tier IV: likely benign. Most oncologists focus discussion on Tier I and II.
Variants of Unknown Significance (VUS)
Genetic changes identified but not yet classified as pathogenic or benign. Common in comprehensive reports. Most are not actionable now. They should not generate disproportionate anxiety -- they are documented, not diagnosed.
Frequently Asked Questions
How CancerFax Helps
CancerFax is a specialist cancer access and patient-navigation platform. We help patients and families understand their options, organise medical records, coordinate hospital communication, and support cross-border treatment planning where appropriate.
We help collect and organise reports, scans, pathology, biomarker results, and treatment history for structured case review.
We communicate with hospitals or trial teams to assess whether a case may be suitable for further screening.
We support appointment coordination, document submission, translation, and direct communication with international departments.
For international patients, we help with practical coordination — travel planning, hospital admission guidance, and local support.
If this option is not suitable, we help explore other relevant treatments, clinical trials, or advanced care pathways.
From inquiry through to follow-up, our coordinators provide a single point of contact for the family.
CancerFax does not guarantee treatment access, eligibility, or clinical outcome. Our role is to help patients access accurate information, structured review, and appropriate specialist pathways.
Need Help Interpreting Your NGS Report?
CancerFax helps patients understand which findings in their NGS report are clinically significant and connects them with oncologists who can explain what each finding means for treatment.
This content is for informational purposes only and does not constitute medical advice. Always consult a qualified oncologist before making treatment decisions.