In this article
SIRT Combined with Chemotherapy for Metastatic Colorectal Cancer
New research shows that in patients with liver or liver-dominant metastatic colorectal cancer , the addition of selective internal radiation therapy to standard first-line mFOLFOX6 chemotherapy results in a significant increase in the survival of patients with primary tumors on the right.
SIRT, which has been used in Europe since 2003, is an internal radiotherapy using Y-90 resin microspheres (diameters between 20 and 60 microns) delivered in the hepatic artery using a catheter . Beta radiation emitting microspheres are preferentially placed in the microvessels around the tumor, minimizing systemic effects.
The SIRFLOX, FOXFIRE and FOXFIRE global studies aimed to evaluate the efficacy and safety of SIRT plus first-line oxaliplatin chemotherapy for unresectable mCRC.
Clinical Trial Results and Survival Impact
For 554 patients who received chemotherapy plus SIRT and 549 patients who received chemotherapy only, the results showed that the median survival time of the left tumor of mCRC patients in the chemotherapy plus SIRT group was 24.6 months, compared with 26.6 months in the chemotherapy alone group, but SIRT chemotherapy The median survival of mCRC patients with unilateral tumors was 22 months in the group and 17.1 months in the chemotherapy alone group, which was 5 months longer.
At a news conference, Dr. Harpreet Wasan told Imperial College Health Care NHS Trust in the UK that a hypothesis is that the right side cancer not only […] worsens but is more resistant to chemotherapy. They may be more sensitive to radiation therapy, which has a completely different mechanism of action.
Dr. Wasan added that the lack of positive findings in the overall analysis may be due to the inclusion of patients with metastatic cancer outside the liver. He said: “Although SIRT can control liver diseases, it cannot control diseases outside the liver.”
How CancerFax Helps
CancerFax is a specialist cancer access and patient-navigation platform. We help patients and families understand their options, organise medical records, coordinate hospital communication, and support cross-border treatment planning where appropriate.
We help collect and organise reports, scans, pathology, biomarker results, and treatment history for structured case review.
We communicate with hospitals or trial teams to assess whether a case may be suitable for further screening.
We support appointment coordination, document submission, translation, and direct communication with international departments.
For international patients, we help with practical coordination — travel planning, hospital admission guidance, and local support.
If this option is not suitable, we help explore other relevant treatments, clinical trials, or advanced care pathways.
From inquiry through to follow-up, our coordinators provide a single point of contact for the family.
CancerFax does not guarantee treatment access, eligibility, or clinical outcome. Our role is to help patients access accurate information, structured review, and appropriate specialist pathways.
About Dr. Nishant Mittal
Dr. Nishant Mittal is a highly accomplished researcher with over 13 years of experience in the fields of cardiovascular biology and cancer research. Significant contributions to stem cell biology, developmental biology, and innovative research techniques mark his career. Research Highlights Dr. Mittal's research has focused on several key areas: 1) Cardio…
✓ Reviewed for medical accuracy by the CancerFax review panel.
Medical Disclaimer
This article is for educational purposes only and should not replace medical advice, diagnosis, or treatment from a qualified oncology specialist. Every patient's case is different. Treatment decisions should always be made after a review of complete medical records by the treating medical team.
Treatment availability, eligibility, timelines, and access can change. Any clinical trial participation depends on detailed review and approval by the trial hospital or investigator.