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uMRD Status and Progression-Free Survival in CLL
Venetoclax (Venclexta) and rituximab (Rituxan) are used in combination with relapsed / refractory chronic lymphocytic leukemia ( CLL ), resulting in a high rate of undetectable minimal residual disease ( uMRD ), which is associated with prolonged progression-free survival ( PFS ).
Venetoclax and rituximab-treated patients had almost 5 times the uMRD status as combined with phenytoin and rituximab , and the proportion of patients who maintained this status at 24 months was higher in the venetoclax / rituximab group the 20 or more times. Compared with MRD- positive status, uMRD was associated with a 62 % reduction in risk of disease progression or death .
The MRD status has been proven to predict PFS in CLL patients treated with chemoimmunotherapy , but the predictive value of MRD for new drugs remains uncertain. Data from the random MURANO trial provides an opportunity to examine the predictive value of MRD and CLL without .
MURANO Phase III Trial: Venetoclax Combination Efficacy
MURANO is a phase III randomized trial evaluating the efficacy of rituximab combined with venetoclax versus bendamustine in 389 patients with relapsed / refractory CLL . The patient received 2 years of venetoclax and the first 6 months of rituximab, or 6 months of bendamustine plus rituximab for 6 months.
Preliminary analysis showed that compared with rituximab and bendamustine, the risk of disease progression or death was 84% at 3 years of treatment with venetoclax and rituximab.
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About Susan Hau
Susan Hau is a distinguished researcher in the field of cancer cell therapy, with a particular focus on T cell-based approaches and cancer vaccines. Her work spans several innovative treatment modalities, including CAR T-cell therapy, TIL (Tumor-Infiltrating Lymphocyte) therapy, and NK (Natural Killer) cell therapy. Hau's expertise lies in cancer cell biolo…
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