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FDA Approval of FoundationOne CDx
The FoundationOne CDx (F1CDx) cancer biomarker detection method was approved by the FDA in November 2017 to detect 324 different genes that can identify viable mutations in 5 tumor types including microsatellite instability (MSI) Tumor mutation load. In addition, Keruis molecular map analysis can not only perform genetic testing (the number of detected genes is 592), but also perform protein testing (CISH, pyrosequencing), MSI testing, etc., the testing items are more comprehensive, and the drug selection is more accurate.
These tests are beneficial for patients with high MSI (MSI-H) or mismatch repair defects (dMMR) unresectable or metastatic gastrointestinal tumors, can accept pembrolizumab (Keytruda) and have potential benefits. Detection can also identify other molecular markers and targets to guide treatment. Immune checkpoint inhibitors have shown some surprising results in patients with gastric cancer, especially gastrointestinal MSI-H tumors. Efforts are being made to increase the response rate of checkpoint inhibitors in colon and pancreatic cancer through combination therapy. Researchers are conducting research on a combination of multiple immunotherapy drugs to understand whether they can trigger a response in tumors that are not effective for single-agent therapy. Clinical trials have been designed, and immunotherapy is currently being combined with chemotherapy and radiation therapy in an effort to improve the response rate of these diseases.
Future Outlook for Precision Medicine
Precision medicine will become increasingly mature in the next few years, allowing clinicians to identify biomarkers and targets more effectively than current technologies. Through precision medicine-genetic testing, more cancer patients will have the opportunity to choose the most suitable anti-cancer drugs to improve treatment efficiency, prolong survival and improve quality of life.
How CancerFax Helps
CancerFax is a specialist cancer access and patient-navigation platform. We help patients and families understand their options, organise medical records, coordinate hospital communication, and support cross-border treatment planning where appropriate.
We help collect and organise reports, scans, pathology, biomarker results, and treatment history for structured case review.
We communicate with hospitals or trial teams to assess whether a case may be suitable for further screening.
We support appointment coordination, document submission, translation, and direct communication with international departments.
For international patients, we help with practical coordination — travel planning, hospital admission guidance, and local support.
If this option is not suitable, we help explore other relevant treatments, clinical trials, or advanced care pathways.
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CancerFax does not guarantee treatment access, eligibility, or clinical outcome. Our role is to help patients access accurate information, structured review, and appropriate specialist pathways.
About Sai Sree
✓ Reviewed for medical accuracy by the CancerFax review panel.
Medical Disclaimer
This article is for educational purposes only and should not replace medical advice, diagnosis, or treatment from a qualified oncology specialist. Every patient's case is different. Treatment decisions should always be made after a review of complete medical records by the treating medical team.
Treatment availability, eligibility, timelines, and access can change. Any clinical trial participation depends on detailed review and approval by the trial hospital or investigator.