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Investigative research suggests that diet may play a meaningful role in reducing the risk of pancreatic cancer. The Women's Healthy Diet Changes (WHI-DM) trial — a large randomized controlled trial — examined the impact of dietary fat reduction on pancreatic cancer incidence in postmenopausal women. The trial enrolled 48,835 women aged 50 to 79 between 1993 and 1998, randomly assigning them either to a dietary intervention group with the goal of reducing total fat intake and increasing consumption of vegetables, fruits, and grains, or to a normal diet control group.
The analysis included 46,200 women. In the intervention group, 92 participants were diagnosed with pancreatic cancer, compared to 165 in the control group. Multivariate analysis showed that the intervention group had a pancreatic cancer risk ratio (HR) of 0.86 compared to the control group — a modest overall reduction. However, the benefit was notably stronger in women with a baseline body mass index (BMI) of 25 kg/m² or higher, where the dietary intervention reduced pancreatic cancer risk more significantly, with an HR of 0.71. These findings suggest that a low-fat diet rich in vegetables, fruits, and grains may offer meaningful protection against pancreatic cancer, particularly for overweight postmenopausal women.
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About Dr. Nishant Mittal
Dr. Nishant Mittal is a highly accomplished researcher with over 13 years of experience in the fields of cardiovascular biology and cancer research. Significant contributions to stem cell biology, developmental biology, and innovative research techniques mark his career. Research Highlights Dr. Mittal's research has focused on several key areas: 1) Cardio…
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