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Xinliang Mao
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schoolMD, PhD ยท Tumour Pharmacology

Dr.ย Xinliangย Mao

MD, PhD

Professor of Tumour Pharmacology

corporate_fareGuangzhou Medical University, Guangzhou

check_circleMultiple Myeloma
check_circleDrug Resistance
check_circleNovel Anti-Cancer Agents
check_circleHaematologic Malignancies
INSTITUTION
corporate_fareGuangzhou Medical University
DEPARTMENT
scienceSchool of Basic Medical Sciences
SPECIALTY
medical_servicesMultiple Myeloma & Tumour Pharmacology
LOCATION
location_onGuangzhou, China
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
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Xinliang Mao

MD, PhD

Prof. Xinliang Mao is a Professor of Tumour Pharmacology at Guangzhou Medical University, where he leads the Guangdong Key Laboratory of Protein Modification and Degradation. He is internationally recognised for his work on multiple myeloma drug development, with a particular focus on novel small-molecule agents targeting myeloma survival pathways.

Prof. Mao has built a distinguished research career spanning Soochow University and Guangzhou Medical University, accumulating over 115 peer-reviewed publications and more than 3,800 academic citations. His laboratory has identified and characterised a series of novel anti-myeloma compounds targeting the JAK2/STAT3 signalling pathway, the c-Maf/Otub1 deubiquitinase axis, proteasome inhibition, and CDK9-driven transcription. He has maintained active research collaborations with leading international cancer centres including the Princess Margaret Cancer Centre in Toronto. His work is directly relevant to patients with relapsed or refractory myeloma who have exhausted standard treatment lines and are seeking novel therapeutic strategies.

workspace_premium20+Years Experience
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Visiting Days
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International Patients

CancerFax can coordinate medical-report review and consultation support for international patients seeking a specialist opinion from Prof. Mao, subject to institutional availability and case acceptance.

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Why Consider Prof. Xinliang Mao?

Prof. Mao is one of China's most productive researchers in myeloma pharmacology, with a translational focus that bridges laboratory drug discovery and clinical haematology. Patients with drug-resistant or relapsed myeloma may benefit from his insight into emerging therapeutic targets.

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Pioneer in Myeloma Drug Discovery
Prof. Mao's laboratory has identified multiple novel small-molecule agents with verified preclinical anti-myeloma activity, targeting JAK2/STAT3, PI3K, c-Maf/deubiquitinase pathways, and proteasome inhibition.
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Prolific Publication Record
With over 115 peer-reviewed papers and more than 3,800 citations, Prof. Mao is among the most cited myeloma pharmacology researchers based in China.
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International Research Collaborations
Active collaborative ties with the Princess Margaret Cancer Centre (Toronto) and leading Chinese haematology centres give Prof. Mao's clinical recommendations a broad evidence base.
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Drug Resistance Expertise
Prof. Mao's team specifically investigates resistance mechanisms to proteasome inhibitors and other myeloma agents โ€” directly relevant to patients with relapsed or refractory disease.
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Areas of Specialisation

Translational pharmacology and novel drug development for haematologic malignancies

Prof. Mao's work spans the full translational pipeline from drug target identification through preclinical validation, with a primary focus on multiple myeloma and related haematologic cancers.

Research & Clinical Specialties

Multiple Myeloma Pharmacology

Drug target identification and validation in plasma cell malignancies.

starsJAK2/STAT3 Pathway Inhibition
  • arrow_rightIdentification of small-molecule STAT3 inhibitors with anti-myeloma activity
  • arrow_rightTarget-based high-throughput compound screening
  • arrow_rightPreclinical evaluation in myeloma cell lines and xenograft models
starsc-Maf / Deubiquitinase Axis
  • arrow_rightMechanistic study of c-Maf oncogenic transcription factor in myeloma
  • arrow_rightTargeting Otub1 and USP7 deubiquitinases to induce c-Maf degradation
  • arrow_rightIdentification of natural product-derived compounds disrupting c-Maf stability

Drug Resistance & Novel Agents

Overcoming resistance to standard myeloma therapies through mechanistic research.

starsProteasome Inhibitor Research
  • arrow_rightCharacterisation of resistance mechanisms to bortezomib and related agents
  • arrow_rightDevelopment of novel proteasome inhibitors with improved selectivity profiles
starsCDK9 and Transcriptional Targeting
  • arrow_rightPreclinical evaluation of CDK9 inhibitors in myeloma
  • arrow_rightInvestigation of MYC/MCL-1 downstream pathways as drug targets
Key Disease Areas
check_circleMultiple Myeloma
check_circleDrug-Resistant Haematologic Cancers
check_circleLymphoma
check_circleChronic Myeloid Leukaemia
check_circlePlasma Cell Disorders
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Research Focus & Clinical Approaches

Translational drug development and expert consultation for haematologic malignancies

Prof. Mao's primary contribution is translational โ€” bridging laboratory drug discovery with haematologic oncology clinical practice, particularly for patients with myeloma resistant to existing therapies.

Novel Drug Development Consultation

Medical Oncology

Expert opinion on emerging anti-myeloma agents, including those in preclinical and early clinical development.

Drug Target Assessment
arrow_rightExpert review of molecular target status in patient samples
arrow_rightAssessment of pathway activation (STAT3, PI3K, c-Maf) relevant to therapy selection
arrow_rightGuidance on novel investigational agents for relapsed or refractory myeloma

Second Opinion โ€” Myeloma Management

Second Opinion

Expert review of myeloma diagnosis, staging, and treatment strategy.

Case Review
arrow_rightReview of bone marrow biopsy and cytogenetic/FISH reports
arrow_rightAssessment of pathology, M-protein quantification, and imaging
arrow_rightEvaluation of prior treatment history and resistance patterns
arrow_rightDiscussion of novel and investigational therapeutic options

Drug Resistance Assessment

Complex Disease

Specialist review of resistance mechanisms in relapsed or refractory myeloma.

Resistance Pathway Analysis
arrow_rightIdentification of active survival pathways in refractory myeloma
arrow_rightGuidance on combination strategies to overcome proteasome inhibitor resistance

Monitoring & Follow-Up Opinion

Monitoring

Expert perspective on disease monitoring and response assessment during treatment.

Response Assessment Guidance
arrow_rightInterpretation of MRD (minimal residual disease) testing
arrow_rightGuidance on biomarker monitoring relevant to targeted drug pathways
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Research & Publications

Peer-reviewed contributions to multiple myeloma pharmacology and drug development

Prof. Mao has published over 115 peer-reviewed articles with more than 3,800 academic citations, spanning novel anti-myeloma drug discovery, drug resistance mechanisms, and translational haematologic oncology.

Selected Peer-Reviewed Publications
arrow_rightJAK2-STAT3 inhibitor SC99 displays potent anti-myeloma activity โ€” Oncotarget, 2016
arrow_rightNanchangmycin targets Otub1/c-Maf axis for anti-myeloma activity โ€” Cell Death & Disease, 2020
arrow_rightBruceine B induces c-Maf degradation via proteasomes in myeloma โ€” ACS Pharmacology & Translational Science, 2024
arrow_rightRNF6 auto-ubiquitination induction for myeloma and CML treatment โ€” PMC, 2022
arrow_rightA small-molecule inhibitor of D-cyclin transactivation shows preclinical efficacy in myeloma โ€” Blood, 2011
Research Collaborations & Affiliations
arrow_rightCollaborative research with Princess Margaret Cancer Centre, University Health Network, Toronto
arrow_rightGuangdong Key Laboratory of Protein Modification and Degradation โ€” Guangzhou Medical University
arrow_rightPrior affiliation: Jiangsu Key Laboratory of Translational Research, Soochow University (to 2019)
Research-Led Consultation

Prof. Mao's active research into novel myeloma agents means patients with relapsed or drug-resistant disease may gain access to emerging therapeutic insights through a CancerFax-coordinated consultation.

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Education & Training

Prof. Mao completed his medical and doctoral training in China and conducted postdoctoral research abroad before building his independent academic career at Soochow University and subsequently Guangzhou Medical University.

scheduleExact undergraduate and doctoral institutions have not been confirmed from public sources. The education timeline below reflects verified career positions. Full training history to be updated when official institutional biography becomes available.
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Clinical Experience

Prof. Mao has held full professorial appointments for over 15 years across two leading Chinese research universities, building one of China's most productive laboratories in myeloma pharmacology and novel drug development.

Professor of Tumour Pharmacology
Guangzhou Medical University
School of Basic Medical Sciences & Guangdong Key Laboratory of Protein Modification and Degradation
check_circleMultiple Myeloma Drug Target Identification and Validation
check_circleSmall-Molecule Anti-Cancer Agent Development
check_circleProteasome Inhibitor Resistance Research
check_circlec-Maf/Deubiquitinase Pathway Mechanistic Research
check_circleInternational Collaborative Research (Princess Margaret Cancer Centre)
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Languages & International

Prof. Mao conducts consultations and research communications in the following languages.

๐Ÿ‡จ๐Ÿ‡ณMandarin Chinese
๐Ÿ‡ฌ๐Ÿ‡งEnglish
Interpreter Support Available

CancerFax can coordinate certified medical interpreters for patients who require support in languages beyond Mandarin and English.

CancerFax can coordinate professional medical interpreter support for patients consulting in other languages.

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How CancerFax Helps You Access Dr. Xinliang Mao

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Xinliang Mao's team โ€” with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history โ€” prepared as a structured clinical summary for Dr. Xinliang Mao's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Xinliang Mao before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Xinliang Mao's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Xinliang Mao's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Xinliang Mao's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Prof. Xinliang Mao

CancerFax can coordinate medical-report review and consultation support for international patients seeking an expert opinion from Prof. Mao at Guangzhou Medical University, subject to institutional availability and case acceptance.

Prof. Mao's primary focus is multiple myeloma, including relapsed and refractory cases resistant to standard therapies such as proteasome inhibitors and immunomodulatory drugs. His broader research also covers lymphoma, chronic myeloid leukaemia, and other haematologic malignancies.

Submit your medical reports through CancerFax using the Send Your Reports option. The CancerFax team will review the documents, prepare the case summary, and coordinate the next steps with the hospital, subject to availability.

A second-opinion request can be submitted through CancerFax with the patient's bone marrow biopsy reports, cytogenetic and FISH results, M-protein data, imaging, and prior treatment history. The final consultation format and availability depend on Prof. Mao's institution.

Prof. Mao's laboratory has specifically investigated resistance mechanisms to proteasome inhibitors and other myeloma agents, and has identified novel therapeutic targets including JAK2/STAT3, c-Maf/deubiquitinase pathways, and CDK9. This research focus is directly relevant to patients whose disease has stopped responding to standard treatments and who are exploring next-line options.

Prof. Mao's work is primarily translational and laboratory-based. Patients interested in access to investigational agents or clinical trials at Guangzhou Medical University should submit their case through CancerFax, and the team will assess current opportunities subject to eligibility and availability.

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Connect with Xinliang Mao Today

Share your medical reports for a free preliminary review. Our patient coordinators will help you understand your options and arrange a direct consultation.

Free case review ยท No commitment ยท Response within 24 hours ยท Available in 12+ languages

Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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