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Steven Rosenberg
verifiedCancerFax Verified
schoolMD, PhD Β· Johns Hopkins & Harvard

Dr.Β StevenΒ Rosenberg

MD, PhD

Chief, Surgery Branch, National Cancer Institute

corporate_fareNational Cancer Institute, Bethesda, MD

check_circleTIL Therapy
check_circleAdoptive Cell Therapy
check_circleCancer Immunotherapy
check_circleMelanoma & Solid Tumours
INSTITUTION
corporate_fareNational Cancer Institute
DEPARTMENT
scienceSurgery Branch
SPECIALTY
medical_servicesSurgical Oncology & Cancer Immunotherapy
LOCATION
location_onBethesda, MD, USA
person

Steven Rosenberg

MD, PhD

Dr. Steven A. Rosenberg is a surgeon-scientist and Chief of the Surgery Branch at the National Cancer Institute (NCI) in Bethesda, Maryland. He is recognised as a pioneer of cancer immunotherapy, with foundational work in tumour-infiltrating lymphocyte (TIL) therapy and adoptive cell transfer for advanced cancer.

Dr. Rosenberg has led the NCI Surgery Branch since 1974, building an internationally recognised cancer immunotherapy research programme at the NIH Clinical Center. His studies of interleukin-2 led to its US FDA approval for metastatic melanoma and renal cancer, and his cell-transfer immunotherapy work produced durable complete remissions in patients with advanced melanoma. He pioneered gene therapy and was the first to successfully insert foreign genes into humans, and his laboratory contributed to the early clinical development of CAR T-cell therapy for aggressive lymphomas. His more recent work develops personalised T-cell therapies that target unique mutations in a patient's cancer. He has published more than 1,200 peer-reviewed papers and received the 2023 National Medal of Technology and Innovation, the United States' highest honour for technological achievement.

workspace_premium50+Years Experience
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Visiting Days
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International Patients

Access to NCI Surgery Branch immunotherapy is through research protocols with protocol-specific eligibility screening. CancerFax can help international patients organise their medical records and prepare a structured case summary for specialist or clinical-trial review, subject to eligibility and the trial team's acceptance.

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Why Consider Dr. Steven Rosenberg?

Dr. Rosenberg's work has shaped modern cancer immunotherapy and remains central to advanced cell-therapy research for melanoma and solid tumours.

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National Medal of Technology
Recipient of the 2023 National Medal of Technology and Innovation, the United States' highest honour for technological achievement, for his work in cancer immunotherapy.
science
TIL Therapy Pioneer
Developed tumour-infiltrating lymphocyte therapy and adoptive cell transfer, the foundation behind the first FDA-approved TIL therapy for advanced melanoma.
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Gene & Cell Therapy Foundations
First to successfully insert foreign genes into humans and an early contributor to CAR T-cell clinical development.
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International Case Support
CancerFax coordinates medical-report review and case preparation for patients seeking evaluation for advanced immunotherapy research.
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Areas of Specialization

Cancer immunotherapy and adoptive cell therapy

Treatment & Research Specialties

Adoptive Cell Therapy

Cell-based immunotherapies that use a patient's own immune cells to target cancer.

starsTumour-Infiltrating Lymphocyte (TIL) Therapy
  • arrow_rightCollection and laboratory expansion of tumour-derived T cells
  • arrow_rightReinfusion with lymphodepletion and IL-2 support in research protocols
  • arrow_rightFoundational approach behind FDA-approved lifileucel for melanoma
starsEngineered T-Cell Therapy
  • arrow_rightTCR-engineered T cells targeting tumour-specific mutations
  • arrow_rightCAR T-cell approaches studied in lymphoma and solid tumours

Immunotherapy for Advanced Cancer

Systemic immune-based treatments for metastatic disease.

starsInterleukin-2 (IL-2) Immunotherapy
  • arrow_rightHigh-dose IL-2 for selected metastatic melanoma and renal cancer
  • arrow_rightBasis of the FDA-approved IL-2 immunotherapy
starsMutation-Targeted Immunotherapy
  • arrow_rightPersonalised T-cell therapy targeting patient-specific cancer mutations
  • arrow_rightApplied to selected epithelial solid tumours in research settings
Clinical & Research Focus Areas
check_circleMetastatic Melanoma
check_circleAdvanced Solid Tumours
check_circleGastrointestinal Cancers
check_circleBreast Cancer (immunotherapy research)
check_circlePancreatic Cancer (immunotherapy research)
medical_services

Clinical & Research Services

Investigational immunotherapy and specialist evaluation

Dr. Rosenberg's clinical work is delivered through NCI Surgery Branch research protocols at the NIH Clinical Center. The services below reflect investigational immunotherapy and specialist review rather than routine outpatient care.

Adoptive Cell Therapy Programmes

Medical Oncology

Administration of cell-based immunotherapies within NCI research protocols.

Cell Therapy Approaches
arrow_rightTIL therapy with lymphodepleting chemotherapy and IL-2 support
arrow_rightTCR- and CAR-engineered T-cell transfer
arrow_rightPersonalised mutation-targeted T-cell therapy

Specialist Immunotherapy Evaluation

Complex Disease

Assessment of advanced or treatment-refractory cancers for cell-therapy approaches.

Evaluation Focus
arrow_rightSuitability review for TIL or adoptive cell therapy
arrow_rightTumour tissue and biomarker considerations
arrow_rightAssessment after prior immunotherapy or targeted therapy

Multidisciplinary Trial Review

Multidisciplinary

Coordinated review for clinical-trial-based immunotherapy.

Trial Pathway
arrow_rightProtocol-specific eligibility screening
arrow_rightCoordination across surgery, oncology and cell-therapy teams

Second Opinion Consultations

Second Opinion

Independent expert review of advanced cancer cases.

Case Review
arrow_rightReview of pathology, molecular profiling and imaging
arrow_rightAssessment of immunotherapy and clinical-trial options
arrow_rightGuidance on whether advanced cell therapy may be relevant
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Research & Publications

Foundational cancer immunotherapy research

Selected Peer-Reviewed Publications
arrow_rightDurable complete responses in metastatic melanoma after T-cell transfer immunotherapy
arrow_rightT-cell transfer therapy targeting mutant KRAS in cancer
arrow_rightCancer immunotherapy based on mutation-specific CD4+ T cells in epithelial cancer
arrow_rightMining exomic sequencing data to identify mutated antigens recognised by tumour-reactive T cells
arrow_rightTargeting somatic mutations as a common pathway of human cancer immunotherapy
Research Contributions
arrow_rightPioneered tumour-infiltrating lymphocyte (TIL) therapy and adoptive cell transfer
arrow_rightInterleukin-2 studies leading to FDA approval for melanoma and renal cancer
arrow_rightFirst to successfully insert foreign genes into humans; pioneered gene therapy
arrow_rightEarly clinical development of CAR T-cell therapy for aggressive lymphomas
arrow_rightAuthor of more than 1,200 peer-reviewed publications
Research Profile

Dr. Rosenberg has authored more than 1,200 peer-reviewed papers. A fuller publication list is available through NIH and PubMed.

school

Education & Training

Dr. Rosenberg trained at Johns Hopkins and Harvard before completing surgical residency in Boston and joining the National Cancer Institute.

Undergraduate
BA
Johns Hopkins University, Baltimore, USA
1961
Medical Degree
MD
Johns Hopkins University School of Medicine, Baltimore, USA
1964
Doctorate
PhD in Biophysics
Harvard University, Cambridge, USA
1969
Doctoral research on the proteins of erythrocyte membranes.
Residency
Surgical Residency
Peter Bent Brigham Hospital, Boston, USA
1974
Completed residency training in surgery, alongside a research fellowship in immunology at Harvard Medical School.
work_history

Clinical Experience

Dr. Rosenberg has led the NCI Surgery Branch since 1974, where his laboratory and clinical programme have shaped modern cancer immunotherapy.

Chief, Surgery Branch
National Cancer Institute (NCI), Center for Cancer Research
NIH Clinical Center, Bethesda, MD
check_circleTumour-infiltrating lymphocyte (TIL) therapy development
check_circleAdoptive cell transfer for metastatic cancer
check_circleMutation-targeted personalised T-cell therapy
check_circleClinical immunotherapy programme for breast, GI and pancreatic cancers
check_circleProfessor of Surgery, USUHS and George Washington University
language

Languages & International

Dr. Rosenberg consults in English.

πŸ‡ΊπŸ‡ΈEnglish
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients.

CancerFax can coordinate professional medical interpreter support when required.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Steven Rosenberg

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Steven Rosenberg's team β€” with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history β€” prepared as a structured clinical summary for Dr. Steven Rosenberg's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Steven Rosenberg before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Steven Rosenberg's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Steven Rosenberg's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Steven Rosenberg's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Dr. Steven Rosenberg

Dr. Steven A. Rosenberg is a surgeon-scientist and Chief of the Surgery Branch at the National Cancer Institute (NCI) in Bethesda, Maryland. He is recognised as a pioneer of cancer immunotherapy and is best known for developing tumour-infiltrating lymphocyte (TIL) therapy and adoptive cell transfer.

TIL therapy uses immune cells taken from a patient's own tumour, which are expanded in a laboratory and infused back after preparative treatment. The first FDA-approved TIL therapy (lifileucel) is approved for a specific group of adults with advanced melanoma who have had prior therapy. TIL and related cell therapies for other cancers remain specialised and often investigational, so eligibility must be confirmed by the treating or trial team.

Access to NCI Surgery Branch immunotherapy is through research protocols, which require protocol-specific screening and eligibility confirmation by the trial team. CancerFax can help international patients organise their reports and prepare a structured case summary for review, but acceptance is never guaranteed and is decided by the institution.

Submit your medical reports through CancerFax. Our team reviews the documents, prepares the case, and helps assess whether the cancer type and treatment stage appear relevant for TIL or adoptive cell therapy evaluation, then coordinates next steps with the relevant centre, subject to availability.

His work is most closely associated with metastatic melanoma and advanced solid tumours, including gastrointestinal, breast, and pancreatic cancers, as well as selected lymphomas studied in adoptive cell therapy research.

No. No cancer therapy guarantees a response. Expected benefit, risks, and eligibility vary from patient to patient, and any treatment decision must be made by the qualified treating team after a full review of the medical record.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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