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Raajit Rampal
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schoolMD, PhD – Molecular & Cellular Biology

Dr.Β RaajitΒ Rampal

MD, PhD

Associate Member & Director, Center for Hematologic Malignancies

corporate_fareMemorial Sloan Kettering Cancer Center, New York

check_circleJAK Inhibitor Therapy
check_circleMyelofibrosis & MPN
check_circleAML & MDS
check_circlePhysician-Scientist
INSTITUTION
corporate_fareMemorial Sloan Kettering Cancer Center
DEPARTMENT
scienceCenter for Hematologic Malignancies
SPECIALTY
medical_servicesMyeloproliferative Neoplasms, Leukemia & MDS
LOCATION
location_onNew York, USA
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
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Raajit Rampal

MD, PhD

Dr. Raajit K. Rampal is a physician-scientist and Associate Member at Memorial Sloan Kettering Cancer Center (MSKCC), where he serves as Director of the Center for Hematologic Malignancies and Director of the Myeloproliferative Neoplasms (MPN) and Rare Hematologic Malignancies Program. He holds an MD and a PhD in Molecular and Cellular Biology from Stony Brook University, and is board-certified in Internal Medicine, Medical Oncology, and Hematology.

With over 17 years of clinical and research experience at MSKCC, Dr. Rampal specialises in the treatment of myeloproliferative neoplasms β€” including myelofibrosis, polycythemia vera, and essential thrombocythemia β€” as well as acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS), and other rare blood cancers. His laboratory research focuses on the genetic events that drive MPN pathogenesis and transformation to acute leukaemia, with a translational goal of developing novel targeted therapies for patients. Dr. Rampal actively leads and participates in phase 1 and phase 2 clinical trials investigating JAK inhibitors and other molecularly targeted agents. He has co-authored over 150 peer-reviewed publications and is a regular presenter at the American Society of Hematology (ASH) Annual Meeting. His approach to care is personalised, considering each patient's specific disease biology, prior treatments, and family circumstances.

workspace_premium17+Years Experience
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M
Visiting Days
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International Second Opinion

CancerFax can coordinate medical-record review and second-opinion support for international patients seeking a consultation with Dr. Rampal at Memorial Sloan Kettering Cancer Center.

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Why Consider Dr. Raajit Rampal?

Dr. Rampal is one of the world's foremost authorities on myeloproliferative neoplasms and myeloid malignancies. Patients with complex MPN, myelofibrosis, AML evolved from MPN, or rare haematological conditions travel from across the globe to seek his expertise at MSKCC.

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Leading MPN Specialist at MSKCC
Director of both the Center for Hematologic Malignancies and the MPN and Rare Hematologic Malignancies Program at one of the world's top cancer centres, with over 17 years of focused clinical experience.
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Physician-Scientist with 150+ Publications
Dr. Rampal runs an active laboratory programme alongside his clinical work, with over 150 peer-reviewed publications focused on MPN pathogenesis, JAK inhibitor therapy, and prevention of leukaemic transformation.
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Active Clinical Trial Leadership
He leads and co-investigates multiple phase 1 and phase 2 trials at MSKCC, including studies of novel JAK inhibitor combinations and investigational agents for myelofibrosis and related conditions.
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Globally Sought for Second Opinions
International patients and physicians frequently seek Dr. Rampal's opinion on complex MPN cases. CancerFax can help coordinate the medical record submission and second-opinion process.
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Areas of Specialisation

Dr. Rampal's clinical and research focus spans myeloproliferative neoplasms, myeloid leukaemia, and rare haematologic malignancies.

Dr. Rampal's practice centres on the full spectrum of myeloproliferative neoplasms β€” from polycythemia vera and essential thrombocythemia to myelofibrosis and MPN-related acute myeloid leukaemia. He combines deep molecular expertise with broad clinical experience in AML, MDS, and rare blood cancers.

Clinical Specialities

Myeloproliferative Neoplasms (MPN)

Comprehensive management of MPN including disease risk stratification, symptom-directed therapy, JAK inhibitor treatment, and monitoring for disease progression or leukaemic transformation.

starsMyelofibrosis
  • arrow_rightPrimary and secondary myelofibrosis management
  • arrow_rightJAK inhibitor therapy including ruxolitinib and momelotinib
  • arrow_rightAnaemia management in myelofibrosis
  • arrow_rightAssessment for stem cell transplantation eligibility
starsPolycythemia Vera & Essential Thrombocythemia
  • arrow_rightRisk-adapted treatment planning for PV and ET
  • arrow_rightCytoreductive therapy and phlebotomy management
  • arrow_rightMonitoring for transformation to myelofibrosis or AML

Myeloid Leukaemia & Related Disorders

Expert management of AML arising de novo and from prior MPN or MDS, along with myelodysplastic syndrome and systemic mastocytosis.

starsAcute Myeloid Leukaemia (AML)
  • arrow_rightAML arising from MPN or MDS (secondary AML)
  • arrow_rightMolecularly targeted therapy based on somatic mutation profile
  • arrow_rightPhase 1 and phase 2 investigational therapy trials
  • arrow_rightTransplant-eligibility assessment and referral coordination
starsMyelodysplastic Syndrome (MDS)
  • arrow_rightRisk stratification and individualised treatment planning
  • arrow_rightSupportive care including transfusion management
  • arrow_rightTargeted therapy where molecularly applicable
starsSystemic Mastocytosis & Rare Haematologic Malignancies
  • arrow_rightSystemic mastocytosis diagnosis and management
  • arrow_rightHairy cell leukaemia and related rare conditions
  • arrow_rightComplex cases reviewed within MSKCC multidisciplinary team
Cancer Types & Conditions Treated
check_circleMyelofibrosis (Primary & Secondary)
check_circlePolycythemia Vera
check_circleEssential Thrombocythemia
check_circleAcute Myeloid Leukaemia (AML)
check_circleMyelodysplastic Syndrome (MDS)
check_circleSystemic Mastocytosis
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Procedures & Clinical Approaches

Treatment services and clinical pathways offered by Dr. Rampal at MSKCC

Dr. Rampal offers evidence-based and investigational treatment approaches for patients with MPN, myeloid leukaemia, and related disorders. His clinical services span front-line treatment planning, JAK inhibitor therapy, participation in novel clinical trials, and second-opinion consultations.

JAK Inhibitor & Targeted Therapy

Targeted Therapy

Dr. Rampal is an internationally recognised expert in JAK inhibitor therapy for myelofibrosis and MPN. He provides molecularly guided treatment selection based on mutation profiling and disease stage.

JAK Inhibitor Treatments
arrow_rightRuxolitinib for myelofibrosis and polycythemia vera
arrow_rightMomelotinib for myelofibrosis with anaemia
arrow_rightCombination JAK inhibitor strategies in clinical trials
arrow_rightTargeted agents based on somatic mutation profile (e.g. IDH1/2, FLT3)

Clinical Trial Participation

Medical Oncology

Dr. Rampal leads and co-investigates multiple phase 1 and phase 2 trials at MSKCC for patients with MPN and myeloid malignancies.

Active Investigational Studies
arrow_rightPhase 1 study of AJ1-11095 in myelofibrosis
arrow_rightPhase 1 study of ruxolitinib plus abemaciclib for myelofibrosis
arrow_rightPhase 1b/2a study of DISC-0974 in myelofibrosis and anaemia
arrow_rightPhase 2 study of momelotinib combined with luspatercept for myelofibrosis

Haematology Diagnostic Procedures

Diagnosis

Comprehensive diagnostic evaluation and monitoring for blood and bone marrow disorders.

Diagnostic Services
arrow_rightBone marrow aspiration and biopsy interpretation
arrow_rightMolecular profiling and mutation analysis (JAK2, CALR, MPL and others)
arrow_rightDisease monitoring and response assessment
arrow_rightTransfusion management for anaemia in MPN/MDS

Second Opinion Consultation

Second Opinion

Dr. Rampal provides expert second opinions for patients with MPN, AML, MDS, and rare haematologic conditions. International patients can submit reports through CancerFax for review and coordination.

Second Opinion Services
arrow_rightReview of pathology, bone marrow reports, and molecular studies
arrow_rightTreatment plan assessment and alternative recommendations
arrow_rightVirtual consultation availability through MSKCC
arrow_rightCoordination supported by CancerFax for international patients
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Research & Publications

Peer-reviewed contributions in MPN pathogenesis, JAK inhibitor therapy, and myeloid malignancy

Dr. Rampal has co-authored over 150 peer-reviewed articles and is one of the most cited researchers in the field of myeloproliferative neoplasms. His laboratory at MSKCC uses primary patient samples to study the genetic drivers of MPN and leukemic transformation, with a direct translational focus on developing novel targeted treatments.

Selected Peer-Reviewed Publications
arrow_rightPrevention and treatment of transformation of myeloproliferative neoplasms to acute myeloid leukaemia – Haematologica (2025)
arrow_rightAccelerated and Blast Phase Myeloproliferative Neoplasms – Hematology/Oncology Clinics of North America (2021)
arrow_rightPathogenesis and management of acute myeloid leukaemia that has evolved from a myeloproliferative neoplasm – Current Opinion in Hematology (2014)
arrow_rightOver 150 peer-reviewed articles on MPN pathogenesis, JAK inhibitor therapy, and leukaemic transformation
Clinical Trial Investigations
arrow_rightInvestigator – Phase 1 Study of AJ1-11095 in Myelofibrosis (MSKCC)
arrow_rightInvestigator – Phase 1 Study of Ruxolitinib plus Abemaciclib for Myelofibrosis (MSKCC)
arrow_rightCo-Investigator – Phase 1b/2a Study of DISC-0974 in Myelofibrosis and Anaemia (MSKCC)
arrow_rightCo-Investigator – Phase 2 Study of Momelotinib Combined with Luspatercept for Myelofibrosis (MSKCC)
Professional & Academic Contributions
arrow_rightRegular presenter at American Society of Hematology (ASH) Annual Meeting
arrow_rightFeatured speaker at ASCO 2024 Myelofibrosis Roundtable
arrow_rightProfessional activities with MPN Research Foundation
arrow_rightListed specialist – Aplastic Anemia and MDS International Foundation (AAMDS)
Physician-Scientist

Dr. Rampal combines active laboratory research with clinical practice, meaning patients at MSKCC benefit directly from his ongoing work to develop novel targeted therapies for MPN and myeloid leukaemia.

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Education & Training

Dr. Rampal completed his undergraduate, medical, and doctoral training at Stony Brook University, followed by residency at the University of Chicago and fellowship and postdoctoral training at Memorial Sloan Kettering Cancer Center.

Undergraduate
BS, Biochemistry
Stony Brook University, New York, USA
Early 1990s – late 1990s
Medical & Doctoral
MD, PhD (Molecular and Cellular Biology)
Stony Brook University School of Medicine, New York, USA
– 2007
Combined MD/PhD programme with doctoral research in molecular and cellular biology, providing a dual foundation in clinical medicine and laboratory science.
Residency
Internal Medicine Residency
University of Chicago Hospitals, Chicago, USA
2007 – 2010
Fellowship
Hematology / Oncology Fellowship
Memorial Sloan Kettering Cancer Center, New York, USA
2010 – 2013
Postdoctoral Training
Postdoctoral Research (Ross Levine Laboratory)
Memorial Sloan Kettering Cancer Center, New York, USA
2010 – 2013
Postdoctoral laboratory training in the Ross Levine Lab focused on the molecular pathogenesis of myeloid malignancies.
Board Certification
Board Certification – Internal Medicine, Medical Oncology, Hematology
American Board of Internal Medicine (ABIM)
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Clinical Experience

Dr. Rampal has spent his entire post-training career at Memorial Sloan Kettering Cancer Center, where he has progressed to hold concurrent leadership roles directing the Centre for Hematologic Malignancies and the MPN and Rare Hematologic Malignancies Program.

Associate Member & Director, Center for Hematologic Malignancies
Memorial Sloan Kettering Cancer Center
MPN and Rare Hematologic Malignancies Program
check_circleMyeloproliferative neoplasm management and JAK inhibitor therapy
check_circleAML and MDS arising from MPN – diagnosis and treatment
check_circleActive clinical trial leadership in myelofibrosis and myeloid malignancy
check_circleTranslational laboratory research on MPN pathogenesis
check_circleSecond-opinion consultations for complex haematologic cases
check_circleMultidisciplinary care planning within MSKCC's haematology team
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Languages & International

Dr. Rampal consults in the following language.

πŸ‡ΊπŸ‡ΈEnglish
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients requiring assistance in languages other than English.

CancerFax can coordinate professional medical interpreter support for international patients consulting with Dr. Rampal.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Raajit Rampal

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Raajit Rampal's team β€” with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history β€” prepared as a structured clinical summary for Dr. Raajit Rampal's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Raajit Rampal before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Raajit Rampal's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Raajit Rampal's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Raajit Rampal's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Dr. Raajit Rampal

Dr. Rampal specialises in myeloproliferative neoplasms (MPN) including myelofibrosis, polycythemia vera, and essential thrombocythemia, as well as acute myeloid leukaemia (AML) β€” particularly AML arising from prior MPN or MDS β€” myelodysplastic syndrome (MDS), systemic mastocytosis, and other rare haematologic malignancies.

Yes. Dr. Rampal at Memorial Sloan Kettering Cancer Center offers second-opinion consultations, and virtual visits are available through MSKCC. CancerFax can help international patients organise and submit their medical reports β€” including pathology, bone marrow reports, imaging, and mutation studies β€” and coordinate the next steps with the hospital, subject to availability and case acceptance.

Submit your medical records through the CancerFax upload portal. The CancerFax team will review the documents, prepare a structured medical summary, and coordinate submission and communication with Memorial Sloan Kettering Cancer Center on your behalf. The timeline and format of the consultation depend on MSKCC's availability.

Dr. Rampal is one of the world's foremost experts in JAK inhibitor therapy for myelofibrosis and MPN. He has extensive experience with ruxolitinib, momelotinib, and investigational JAK inhibitor combinations, and he regularly presents advances in this area at the American Society of Hematology (ASH) Annual Meeting. He also leads clinical trials evaluating novel JAK inhibitor combinations at MSKCC.

Yes. Dr. Rampal actively leads and co-investigates multiple phase 1 and phase 2 clinical trials at MSKCC. These include studies of ruxolitinib plus abemaciclib, momelotinib combined with luspatercept, and novel investigational agents such as AJ1-11095 and DISC-0974 for patients with myelofibrosis and related conditions. Eligibility for any trial depends on individual clinical and molecular criteria.

Dr. Raajit Rampal is based at Memorial Sloan Kettering Cancer Center (MSKCC) at 1275 York Avenue, New York, NY 10065, USA. He serves as Associate Member and Director of the Center for Hematologic Malignancies and the MPN and Rare Hematologic Malignancies Program.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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