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Jianming Xu
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schoolPhD Pharmacology · Academy of Military Medical Sciences

Dr. Jianming Xu

Bachelor of Clinical Medicine, Master of Oncology, PhD in Pharmacology

Professor & Director, Department of Gastrointestinal Oncology

corporate_fareFifth Medical Center, Chinese PLA General Hospital, Beijing

check_circleGI Oncology
check_circleImmunotherapy
check_circleTargeted Therapy
check_circlePhase I–III Trials
INSTITUTION
corporate_fareFifth Medical Center, Chinese PLA General Hospital
DEPARTMENT
scienceGastrointestinal Oncology
SPECIALTY
medical_servicesImmunotherapy, Targeted Therapy & Phase I Trials
LOCATION
location_onBeijing, China
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
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Jianming Xu

Bachelor of Clinical Medicine, Master of Oncology, PhD in Pharmacology

Prof. Jianming Xu is Professor and Director of Gastrointestinal Oncology at the Fifth Medical Center, Chinese PLA General Hospital, Beijing — one of China's leading tertiary oncology centres. He has dedicated more than 35 years to the clinical management and translational research of advanced digestive system cancers.

Prof. Xu's clinical work centres on gastric cancer, colorectal cancer, oesophageal cancer, hepatocellular carcinoma, pancreatic cancer, gastrointestinal stromal tumours, and neuroendocrine tumours. He is widely recognised for leadership in immunotherapy, anti-angiogenic targeted therapy, and early-phase clinical trials, and has served as principal investigator in landmark studies including ORIENT-16 and RATIONALE-306. The Chinese Anti-Cancer Association reports over 100 peer-reviewed publications in journals including The Lancet Oncology, Journal of Clinical Oncology, and Nature Communications. He has received the 8th Chinese Physician Award and the National Famous Doctor – Outstanding Achievement honour. Prof. Xu also served a two-year period as Consultant Physician at Italy's National Cancer Institute, contributing to his international academic perspective.

workspace_premium35+Years Experience
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Visiting Days
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International Patients

CancerFax can coordinate medical-report review and consultation support for international patients seeking an expert gastrointestinal oncology opinion from Prof. Xu, subject to hospital availability and case acceptance.

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Why Consider Prof. Jianming Xu?

Prof. Xu combines a 35-year clinical career, landmark phase III trial leadership, and more than 100 international publications to offer patients with advanced gastrointestinal cancers access to precision, evidence-based treatment strategies.

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Nationally Recognised GI Oncology Leader
Recipient of the 8th Chinese Physician Award and the National Famous Doctor – Outstanding Achievement honour, with leadership roles in Chinese Anti-Cancer Association committees and CSCO expert panels.
science
Phase I–III Clinical Trial Principal Investigator
PI or lead investigator in ORIENT-16 (sintilimab in gastric cancer), RATIONALE-306 (tislelizumab in oesophageal cancer), the RESCUE trial (camrelizumab plus apatinib in hepatocellular carcinoma), and the SANET neuroendocrine tumour programme.
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Precision Immunotherapy & Targeted Therapy Expertise
Deep expertise in PD-1/PD-L1 checkpoint inhibitor combinations, anti-angiogenic therapy, HER2-directed strategies, and biomarker-guided treatment for gastric, liver, oesophageal, and colorectal cancers.
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International Academic & Clinical Experience
In addition to his PLA General Hospital role, Prof. Xu served as Consultant Physician at Italy's National Cancer Institute and publishes extensively in leading international oncology journals.
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Areas of Specialisation

Advanced gastrointestinal oncology with a focus on immunotherapy, targeted therapy, and clinical trial development

Prof. Xu specialises in the full spectrum of gastrointestinal malignancies. His practice integrates modern systemic therapies — including immune checkpoint inhibitors, anti-angiogenic agents, and HER2-directed regimens — with precision biomarker-guided decision-making for each patient.

Treatment Specialties

Immunotherapy & Checkpoint Inhibition

PD-1 and PD-L1 inhibitor-based regimens for gastric, oesophageal, and liver cancers.

starsPD-1/PD-L1 Inhibitor Combinations
  • arrow_rightSintilimab plus chemotherapy in advanced gastric/GEJ adenocarcinoma (ORIENT-16)
  • arrow_rightTislelizumab plus chemotherapy in advanced oesophageal squamous cell carcinoma (RATIONALE-306)
  • arrow_rightCamrelizumab plus apatinib in advanced hepatocellular carcinoma (RESCUE trial)
  • arrow_rightBiomarker-led patient selection including PD-L1 expression and MSI/MMR testing
starsImmunotherapy-Antiangiogenic Combinations
  • arrow_rightCombined checkpoint inhibitor and anti-angiogenic therapy for hepatocellular carcinoma
  • arrow_rightEvaluation of treatment response and duration for eligible patients

Targeted Therapy & Precision Oncology

Molecularly guided systemic treatment for GI cancers including HER2-directed and anti-angiogenic strategies.

starsHER2-Directed Therapy
  • arrow_rightTrastuzumab-based first-line treatment in HER2-positive gastric and GEJ adenocarcinoma
  • arrow_rightEvaluation of novel HER2-targeting agents including bispecific antibody anbenitamab (KC-WISE study)
  • arrow_rightSequencing decisions in HER2-positive gastric cancer following first-line progression
starsAnti-Angiogenic Therapy
  • arrow_rightApatinib and related anti-VEGF/VEGFR agents in advanced gastric and hepatocellular carcinoma
  • arrow_rightCombination anti-angiogenic and immunotherapy strategies
starsSurufatinib & Neuroendocrine Tumour Therapy
  • arrow_rightSurufatinib in advanced pancreatic neuroendocrine tumours (SANET-p)
  • arrow_rightSurufatinib in advanced extra-pancreatic neuroendocrine tumours (SANET-ep)
  • arrow_rightSystemic therapy for neuroendocrine carcinoma

Early-Phase & Emerging Therapies

Phase I and investigator-initiated studies exploring next-generation oncology treatments.

starsmRNA Neoantigen Vaccine Research
  • arrow_rightInvestigator-initiated study of personalised neoantigen vaccine in advanced gastric, oesophageal, and liver cancers (ClinicalTrials.gov NCT05192460)
starsCAR-T Cell Therapy in Solid Tumours
  • arrow_rightPhase I study of NKG2D-based CAR-T therapy in advanced NKG2DL-positive solid tumours and hepatocellular carcinoma
Cancer Types Treated
check_circleGastric & Gastroesophageal Junction Cancer
check_circleColorectal Cancer
check_circleOesophageal Cancer (ESCC)
check_circleHepatocellular Carcinoma
check_circlePancreatic Cancer
check_circleGastrointestinal Stromal Tumours (GIST)
check_circleNeuroendocrine Tumours & Carcinoma
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Procedures Performed

Systemic therapy, trial-based treatment, and expert consultation for gastrointestinal cancers

Prof. Xu's practice covers the full range of medical oncology services for advanced gastrointestinal malignancies, from first-line systemic therapy through clinical trial enrolment, precision biomarker-guided planning, and expert second opinions.

Systemic Therapy for GI Cancers

Medical Oncology

Comprehensive chemotherapy and combined systemic treatment regimens for advanced gastrointestinal cancers.

Chemotherapy Regimens
arrow_rightFLOT, FOLFOX, XELOX, and SOX regimens for gastric and colorectal cancer
arrow_rightPaclitaxel and fluorouracil-based regimens for oesophageal cancer
arrow_rightGemcitabine-based regimens for pancreatic cancer

Immunotherapy Treatment Planning

Targeted Therapy

PD-1/PD-L1 inhibitor-based treatment with biomarker-driven patient selection.

Checkpoint Inhibitor Protocols
arrow_rightCombination immunotherapy plus chemotherapy for first-line gastric and oesophageal cancer
arrow_rightImmunotherapy plus anti-angiogenic therapy for hepatocellular carcinoma
arrow_rightPD-L1, MSI/MMR, and TMB biomarker-guided treatment selection

Clinical Trial Participation & Enrolment

Complex Disease

Access to investigational therapies through active phase I, II, and III studies in gastrointestinal oncology.

Active Research Areas
arrow_rightPhase III trials in advanced gastric, GEJ, oesophageal, liver, and neuroendocrine tumours
arrow_rightInvestigator-initiated neoantigen vaccine study in gastric, oesophageal, and liver cancers
arrow_rightPhase I CAR-T therapy in NKG2DL-positive solid tumours

Staging, Diagnostics & Biomarker Evaluation

Diagnosis

Molecular and imaging-guided staging to inform personalised treatment planning.

Diagnostic Evaluation
arrow_rightHER2 status testing and interpretation for gastric/GEJ adenocarcinoma
arrow_rightPD-L1 IHC, MSI/MMR, and tumour mutational burden assessment
arrow_rightPathology and imaging review for advanced GI cancers

Expert Second Opinion

Second Opinion

Independent oncology review of pathology, imaging, and treatment history for complex GI cancer cases.

Second Opinion Process
arrow_rightReview of pathology reports, molecular profiling, and prior treatment records
arrow_rightAssessment of treatment options including immunotherapy and targeted therapy eligibility
arrow_rightEvaluation of clinical trial suitability for advanced or refractory disease
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Research & Publications

Over 100 international peer-reviewed publications and principal investigator roles in landmark GI oncology trials

Prof. Xu has made major contributions to gastrointestinal oncology through phase II and phase III clinical trial leadership, translational research in immunotherapy and targeted therapy, and international peer-reviewed publications. The Chinese Anti-Cancer Association reports over 100 papers in journals including The Lancet Oncology, Journal of Clinical Oncology, Science Advances, Nature Communications, and Clinical Cancer Research.

Landmark Clinical Trial Publications
arrow_rightRESCUE trial — camrelizumab plus apatinib in advanced hepatocellular carcinoma, Clinical Cancer Research (2021)
arrow_rightSANET-p — surufatinib in advanced pancreatic neuroendocrine tumours, The Lancet Oncology (2020)
arrow_rightSANET-ep — surufatinib in advanced extra-pancreatic neuroendocrine tumours, The Lancet Oncology (2020)
arrow_rightRATIONALE-306 — tislelizumab plus chemotherapy in advanced/metastatic oesophageal squamous cell carcinoma, The Lancet Oncology (2023)
arrow_rightORIENT-16 — sintilimab plus chemotherapy in first-line advanced gastric/GEJ adenocarcinoma (Principal Investigator)
Clinical Trial Participation
arrow_rightPrincipal Investigator — ORIENT-16, phase III sintilimab in gastric/GEJ cancer
arrow_rightLead Investigator — RATIONALE-306, phase III tislelizumab in oesophageal squamous cell carcinoma
arrow_rightResponsible Party — NCT05192460, investigator-initiated personalised neoantigen vaccine in gastric, oesophageal, and liver cancers (ClinicalTrials.gov)
arrow_rightInvestigator — Phase I NKG2D-based CAR-T therapy in advanced NKG2DL-positive solid tumours
arrow_rightKD-025 — HER2 bispecific anbenitamab (KC-WISE study) in HER2-positive gastric/GEJ cancer after trastuzumab-based treatment
Research Themes & Academic Roles
arrow_rightImmunotherapy combinations for gastric cancer, oesophageal squamous cell carcinoma, and hepatocellular carcinoma
arrow_rightAnti-angiogenic and immunotherapy combination strategies in liver cancer
arrow_rightSurufatinib and systemic therapy for neuroendocrine tumours and carcinoma
arrow_rightChairman, Chinese Anti-Cancer Association Big Data and Real-World Research Professional Committee
arrow_rightDeputy Chairman, Oncology Professional Committee, Chinese Research Hospital Association
arrow_rightExpert contributor to Chinese NCCN guideline panels: gastric cancer, colorectal cancer, pancreatic cancer
Active Clinical Research

Prof. Xu leads an active clinical trial programme at the Fifth Medical Center. CancerFax can assess whether eligible patients may qualify for ongoing trials as part of the care-coordination process.

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Education & Training

Prof. Xu completed his clinical medicine degree in 1988, followed by a master's degree in oncology and a PhD in pharmacology, both from the Academy of Military Medical Sciences in Beijing.

Undergraduate
Bachelor of Clinical Medicine
Jiangxi Medical College
1983 – 1988
Foundational medical training in clinical medicine, graduating in 1988.
Postgraduate
Master of Oncology
Academy of Military Medical Sciences, Beijing
1991 – 1994
Postgraduate specialisation in oncology.
Doctoral
PhD in Pharmacology
Academy of Military Medical Sciences, Beijing
2006 – 2009
Doctoral research in pharmacology, completed in 2009.
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Clinical Experience

Prof. Xu has built a 35-year career in gastrointestinal oncology at the Chinese PLA General Hospital system, combining clinical leadership with an internationally active research programme. He also served as Consultant Physician at the National Cancer Institute, Italy.

Professor & Director, Department of Gastrointestinal Oncology
Fifth Medical Center, Chinese PLA General Hospital
Department of Gastrointestinal Oncology
check_circleAdvanced GI Cancer Clinical Management
check_circlePhase I–III Clinical Trial Principal Investigator
check_circleImmunotherapy & Anti-Angiogenic Combination Therapy
check_circleNeuroendocrine Tumour Systemic Therapy
check_circleMultidisciplinary Oncology & Guideline Development
check_circleInternational Research Collaboration (Italy NCI)
language

Languages & International

Prof. Xu's verified consultation language is Mandarin Chinese. Language availability for international consultations should be confirmed through the hospital or CancerFax care-coordination team.

🇨🇳Mandarin Chinese
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients seeking a consultation with Prof. Xu.

CancerFax can coordinate professional medical interpreter support for international patients requiring English or other language assistance.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Jianming Xu

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Jianming Xu's team — with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history — prepared as a structured clinical summary for Dr. Jianming Xu's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Jianming Xu before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Jianming Xu's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Jianming Xu's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Jianming Xu's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Prof. Jianming Xu

Prof. Xu specialises in gastrointestinal malignancies including gastric cancer, gastroesophageal junction cancer, colorectal cancer, oesophageal squamous cell carcinoma, hepatocellular carcinoma (liver cancer), pancreatic cancer, gastrointestinal stromal tumours (GIST), and neuroendocrine tumours.

Prof. Xu is Professor and Director of the Department of Gastrointestinal Oncology at the Fifth Medical Center, Chinese PLA General Hospital, Beijing — one of China's leading tertiary oncology hospitals.

CancerFax can coordinate medical-report review and consultation support for international patients seeking an expert opinion from Prof. Xu, subject to hospital availability and case acceptance. Direct teleconsultation availability and language support should be confirmed through the CancerFax team or the hospital's international patient department before travel planning.

Submit your medical reports through CancerFax using the Send Your Reports button. The CancerFax team will review the documents, prepare the case summary, and coordinate the next steps with the hospital, subject to availability.

A second-opinion request can be submitted through CancerFax with the patient's pathology reports, molecular profiling results, imaging studies, prior treatment records, and relevant laboratory results. Prof. Xu can review advanced gastric, oesophageal, colorectal, liver, pancreatic, GIST, and neuroendocrine tumour cases. The final consultation format and timeline depend on the hospital's schedule and case acceptance.

Yes. Prof. Xu is an active clinical trial investigator and has served as Principal Investigator in landmark phase III studies including ORIENT-16 (sintilimab in gastric cancer) and RATIONALE-306 (tislelizumab in oesophageal cancer). He is also the responsible party for an investigator-initiated neoantigen vaccine study in advanced gastric, oesophageal, and liver cancers registered on ClinicalTrials.gov. CancerFax can assess trial eligibility as part of the consultation coordination process.

Yes — these are two different specialists. This page is for Prof. Jianming Xu, gastrointestinal oncologist and Director of Gastrointestinal Oncology at the Fifth Medical Center, Chinese PLA General Hospital, Beijing. Please confirm the specialist's full name when submitting your case through CancerFax.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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