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Eric Jonasch
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schoolMD, Medical Oncology

Dr. Eric Jonasch

MD (Doctor of Medicine)

Professor, Genitourinary Medical Oncology

corporate_fareMD Anderson Cancer Center, Houston, TX

check_circleKidney Cancer & RCC
check_circleVHL Disease
check_circleBelzutifan / HIF-2α
check_circleImmunotherapy
INSTITUTION
corporate_fareMD Anderson Cancer Center
DEPARTMENT
scienceGenitourinary Medical Oncology
SPECIALTY
medical_servicesKidney Cancer, RCC & VHL Disease
LOCATION
location_onHouston, Texas, USA
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
person

Eric Jonasch

MD (Doctor of Medicine)

Dr. Eric Jonasch is a Professor in the Department of Genitourinary Medical Oncology at The University of Texas MD Anderson Cancer Center in Houston, USA. He is internationally recognized as a world authority on kidney cancer, renal cell carcinoma, and von Hippel-Lindau disease, with over 20 years of clinical and research experience.

Dr. Jonasch directs the VHL Clinical Center and co-directs the Kidney Cancer Research Program at MD Anderson, two of the most specialized programs for hereditary and advanced renal cancers in the world. His career has been defined by translating the molecular biology of the VHL-HIF pathway into clinical advances, most notably through his foundational work in the development and evaluation of belzutifan, a first-in-class HIF-2α inhibitor now used in selected patients with VHL-associated tumors and advanced RCC. He serves as Vice-Chair of the NCCN Kidney Cancer Guidelines Panel and has a US chair role with the International Kidney Cancer Coalition, shaping treatment standards globally. His academic output includes hundreds of peer-reviewed publications, clinical trial leadership, and consensus guideline contributions in renal oncology.

workspace_premium20+Years Experience
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Visiting Days
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Why Consider Dr. Eric Jonasch?

Dr. Jonasch is one of the most respected kidney cancer oncologists in the world, combining deep clinical expertise, landmark research, and leadership in shaping global treatment guidelines for RCC and VHL disease.

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World Authority on RCC and VHL Disease
Dr. Jonasch is globally recognized as a leading expert on renal cell carcinoma and von Hippel-Lindau disease, with over two decades of specialised clinical and research experience at MD Anderson Cancer Center.
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Pioneer of Belzutifan and HIF-2α Therapy
He played a pivotal role in the clinical development of belzutifan, the first-in-class HIF-2α inhibitor that has changed treatment options for VHL-associated tumors and advanced RCC after prior systemic therapy.
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NCCN Guideline Leadership
As Vice-Chair of the NCCN Kidney Cancer Guidelines Panel, Dr. Jonasch directly shapes evidence-based treatment standards followed by oncologists across the United States and internationally.
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International Second Opinion Access
CancerFax can facilitate the preparation and coordination of second-opinion requests from international patients with advanced kidney cancer or VHL disease, including report compilation, case summary, and pathway guidance.
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Areas of Specialization

Expert care in kidney cancer, renal cell carcinoma, VHL disease, and genitourinary oncology

Dr. Jonasch's clinical practice and research are focused on systemic treatment of kidney cancer, with particular depth in clear cell renal cell carcinoma, hereditary renal cancer syndromes, and VHL-associated tumour biology. His work spans targeted therapy, immunotherapy, and molecular pathway inhibition.

Treatment Specialties

Kidney Cancer and Renal Cell Carcinoma

Advanced systemic therapy for clear cell RCC, metastatic kidney cancer, and recurrent or treatment-resistant renal cell carcinoma.

starsClear Cell Renal Cell Carcinoma
  • arrow_rightFirst-line systemic therapy planning based on IMDC risk and histology
  • arrow_rightImmunotherapy and VEGF-TKI combination regimens for eligible patients
  • arrow_rightSequencing of therapies after progression on prior lines
starsMetastatic and Recurrent Kidney Cancer
  • arrow_rightTreatment planning for advanced and metastatic RCC
  • arrow_rightBelzutifan and HIF-2α inhibitor strategies for eligible patients
  • arrow_rightClinical trial evaluation for treatment-resistant cases

Von Hippel-Lindau Disease and Hereditary Kidney Cancer

Multidisciplinary management of VHL-associated tumours including renal cell carcinoma, CNS hemangioblastomas, and pancreatic neuroendocrine tumours.

starsVHL-Associated Renal Tumours
  • arrow_rightSurveillance strategy and treatment timing for VHL-related RCC
  • arrow_rightBelzutifan for selected patients requiring systemic therapy
  • arrow_rightCoordination with urology, neurosurgery, and endocrinology teams
starsHereditary Renal Cancer Syndromes
  • arrow_rightGenetic counselling referral and surveillance planning
  • arrow_rightLong-term multidisciplinary management for hereditary tumour syndromes
  • arrow_rightClinical trial access for hereditary kidney cancer programmes

Targeted Therapy and Immunotherapy

Molecularly guided systemic therapy for GU cancers, with expertise in checkpoint inhibitors, VEGF pathway inhibitors, and novel targeted agents.

starsHIF-2α Inhibition
  • arrow_rightBelzutifan treatment for VHL-associated tumours and advanced RCC
  • arrow_rightPatient selection and biomarker-guided treatment planning
starsImmunotherapy and VEGF-Targeted Therapy
  • arrow_rightPD-1/PD-L1 checkpoint inhibitor therapy for kidney cancer
  • arrow_rightCabozantinib, sunitinib, and combination regimen planning
  • arrow_rightTreatment selection based on prior exposure and disease biology
Clinical Focus Areas
check_circleClear Cell Renal Cell Carcinoma
check_circleMetastatic Kidney Cancer
check_circleVon Hippel-Lindau Disease
check_circleVHL-Associated CNS and Pancreatic Tumours
check_circleBelzutifan and HIF-2α Targeted Therapy
check_circleGenitourinary Oncology
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Procedures and Treatment Approaches

Systemic oncology services for kidney cancer and GU malignancies

Dr. Jonasch's clinical work is focused on medical oncology, targeted therapy, and clinical trial-based care for patients with kidney cancer and related genitourinary malignancies. His approach integrates molecular tumour biology, prior treatment history, and patient goals.

Systemic Therapy for Kidney Cancer

Medical Oncology

Comprehensive treatment planning and administration for renal cell carcinoma and advanced GU cancers.

Treatment Options
arrow_rightImmunotherapy regimens including nivolumab and pembrolizumab combinations
arrow_rightVEGF-targeted therapy: sunitinib, cabozantinib, axitinib
arrow_rightBelzutifan (HIF-2α inhibitor) for selected VHL and RCC patients

HIF-2α and Targeted Therapy

Targeted Therapy

Precision systemic therapy guided by molecular tumour profiling and VHL pathway biology.

Targeted Therapy Approaches
arrow_rightBelzutifan for VHL-associated renal, CNS, and pancreatic tumours
arrow_rightBiomarker-driven selection of targeted agents
arrow_rightSequencing strategies after prior VEGF-TKI or immunotherapy

Multidisciplinary Tumour Board and Complex Cases

Multidisciplinary

Complex case review and multidisciplinary coordination for hereditary kidney cancer and VHL disease.

Multidisciplinary Services
arrow_rightTumour board review for complex RCC and VHL cases
arrow_rightCoordination with urologic oncology, neurosurgery, endocrinology, and radiology
arrow_rightSurveillance strategy and treatment timing for hereditary syndromes

Second Opinion and International Consultation

Second Opinion

Expert second opinion for patients with kidney cancer, metastatic RCC, or VHL-associated disease who need advanced treatment guidance.

Second Opinion Services
arrow_rightReview of pathology, imaging, and prior treatment history
arrow_rightAlternative therapy recommendations including clinical trial eligibility
arrow_rightInternational patient case coordination through CancerFax
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Research and Publications

Landmark contributions to kidney cancer, VHL disease, and HIF-2α targeted therapy

Dr. Jonasch is a prolific academic oncologist with hundreds of peer-reviewed publications, clinical trial leadership roles, and major contributions to kidney cancer guidelines. His research has directly influenced modern treatment standards for renal cell carcinoma and VHL-associated disease.

Selected Peer-Reviewed Publications
arrow_rightJonasch E et al. – Belzutifan for renal cell carcinoma in von Hippel-Lindau disease – New England Journal of Medicine, 2021
arrow_rightJonasch E et al. – Clinical management of metastatic renal cell carcinoma – CA: A Cancer Journal for Clinicians
arrow_rightJonasch E et al. – VHL disease: pathogenesis and treatment approaches – Nature Reviews Clinical Oncology
arrow_rightNumerous contributions to NCCN kidney cancer guidelines and ASCO/ESMO consensus publications
Clinical Trial Leadership
arrow_rightLead investigator in pivotal belzutifan trials for VHL-associated tumours and advanced RCC
arrow_rightInvestigator in Phase II and III trials evaluating immunotherapy combinations for clear cell RCC
arrow_rightContributor to cooperative group and investigator-initiated trials in genitourinary oncology
arrow_rightActive involvement in biomarker-driven and HIF pathway inhibition research programmes
Research Profile

Dr. Jonasch's complete publication list is available through PubMed and Google Scholar. A detailed research and trial profile may be requested through the MD Anderson Genitourinary Medical Oncology department.

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Education & Training

Dr. Jonasch completed his undergraduate and medical training at McGill University in Canada, followed by internal medicine residency and specialist hematology-oncology fellowships in Boston. He is board-certified in internal medicine, hematology, and medical oncology.

Undergraduate
B.Sc. in Biochemistry
McGill University, Montreal, Canada
Early 1980s – 1988
Pre-medical undergraduate training in biochemistry at McGill University.
Medical Degree
MDCM (Doctor of Medicine and Master of Surgery)
McGill University Faculty of Medicine, Montreal, Canada
1988 – 1992
Medical degree (MDCM) from McGill University, one of Canada's leading medical schools.
Residency
Internal Medicine Residency
Royal Victoria Hospital, Montreal, Canada
1992 – 1995
Fellowship
Clinical Fellowship – Hematology/Oncology
New England Medical Center, Boston, USA
1995 – 1998
Research Fellowship
Research Fellowship – Oncology
Beth Israel Deaconess Medical Center, Boston, USA
1998 – 2000
Advanced research fellowship focused on cancer biology and translational oncology.
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Clinical Experience

Dr. Jonasch has dedicated his career to kidney cancer and genitourinary oncology at MD Anderson Cancer Center, where he has built two of the most recognised programmes for RCC and VHL disease in the world. His clinical and academic roles have positioned him as a global leader in this field.

Professor, Genitourinary Medical Oncology
The University of Texas MD Anderson Cancer Center
Department of Genitourinary Medical Oncology, Division of Cancer Medicine
check_circleDirector, VHL Clinical Center, MD Anderson
check_circleCo-Director, Kidney Cancer Research Program, MD Anderson
check_circleVice-Chair, NCCN Kidney Cancer Guidelines Panel
check_circleUS Chair, International Kidney Cancer Coalition
check_circle20+ years of specialised kidney cancer clinical and research experience
check_circleClinical trial leadership in RCC and VHL-targeted therapy
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Languages & International

Dr. Jonasch consults in the following language.

🇺🇸English
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients requiring language assistance.

CancerFax can coordinate professional medical interpreter support for international patients consulting with Dr. Jonasch or the MD Anderson Genitourinary Oncology team.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Eric Jonasch

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Eric Jonasch's team — with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history — prepared as a structured clinical summary for Dr. Eric Jonasch's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Eric Jonasch before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Eric Jonasch's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Eric Jonasch's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Eric Jonasch's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Dr. Eric Jonasch

Dr. Eric Jonasch is a Professor of Genitourinary Medical Oncology at The University of Texas MD Anderson Cancer Center in Houston, USA. He is internationally recognised as a world authority on kidney cancer, renal cell carcinoma, and von Hippel-Lindau disease, with over 20 years of specialised clinical and research experience.

Dr. Jonasch primarily specialises in kidney cancer, including clear cell renal cell carcinoma, metastatic RCC, and recurrent or treatment-resistant kidney cancer. He also specialises in von Hippel-Lindau disease and VHL-associated tumours, including renal tumours, CNS hemangioblastomas, and pancreatic neuroendocrine tumours. He treats selected bladder and advanced genitourinary cancers as part of his broader GU oncology practice.

Belzutifan is a first-in-class oral HIF-2α inhibitor approved for selected patients with VHL-associated tumours and advanced renal cell carcinoma after prior systemic therapy. Dr. Jonasch has been closely involved in the clinical research that led to its development and approval, including pivotal trial work evaluating its efficacy in VHL-associated renal tumours, CNS hemangioblastomas, and pancreatic neuroendocrine tumours. His work in this area has directly changed the treatment landscape for patients with VHL disease and advanced RCC.

International patients may seek consultation at MD Anderson Cancer Center, subject to appointment availability and case eligibility. CancerFax can help international patients prepare their medical records, pathology reports, imaging, and prior treatment history for expert review and guide them through the second-opinion and consultation process.

A second-opinion request can be submitted through CancerFax with the patient's pathology reports, imaging files, prior treatment records, molecular or NGS reports, and a summary of current symptoms and performance status. The CancerFax team will review the case, prepare a structured medical summary, and support coordination with the MD Anderson Genitourinary Oncology team. The final consultation format and availability depend on the doctor's schedule and the hospital's case acceptance process.

For a kidney cancer or VHL disease consultation, patients should prepare: the diagnosis and pathology report, immunohistochemistry results, CT or MRI reports and imaging files in DICOM format, surgical notes if a nephrectomy was performed, details of all prior treatments including immunotherapy, targeted therapy, and chemotherapy, genetic testing results especially for VHL or hereditary cancer syndromes, molecular profiling or NGS reports if available, and recent blood tests and organ function reports.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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