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Do-Youn Oh
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schoolMD, PhD · Seoul National University

Dr. Do-Youn Oh

MD, PhD

Professor of Medical Oncology

corporate_fareSeoul National University Hospital, Seoul

check_circleBiliary Tract Cancer
check_circleImmunotherapy & Targeted Therapy
check_circlePancreatic & Gastric Cancer
check_circleFGFR-Directed Therapy
INSTITUTION
corporate_fareSeoul National University Hospital
DEPARTMENT
scienceHemato-Oncology & Medical Oncology Center
SPECIALTY
medical_servicesBiliary Tract Cancer, Pancreatic Cancer, GI Oncology
LOCATION
location_onSeoul, South Korea
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
person

Do-Youn Oh

MD, PhD

Prof. Do-Youn Oh is a Professor of Medical Oncology at Seoul National University Hospital (SNUH), Seoul, South Korea, and one of the world's foremost experts in biliary tract cancer. Her clinical and research work spans gastrointestinal oncology with a particular focus on biliary tract cancer, pancreatic cancer, gastric cancer, and neuroendocrine tumours.

With more than 15 years of clinical and academic experience, Prof. Oh has built an internationally recognised research profile encompassing immunotherapy, targeted therapy, antibody-drug conjugates, and FGFR-directed treatments for gastrointestinal cancers. She served as the overall lead investigator of the landmark global Phase III TOPAZ-1 trial, which enrolled 685 patients across 17 countries and demonstrated a survival benefit for durvalumab combined with gemcitabine and cisplatin in advanced biliary tract cancer — establishing a new first-line standard of care for this difficult-to-treat disease. Her Seoul National University research profile lists over 450 peer-reviewed publications and a Scopus h-index of 78. She is the recipient of the 35th Wunsch Medical Award Main Award.

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Visiting Days
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International Patient Access

Seoul National University Hospital operates an International Healthcare Center. CancerFax can coordinate medical-report review, consultation preparation, and case submission support for international patients seeking an opinion from Prof. Oh.

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Why Consider Prof. Do-Youn Oh?

Prof. Oh is among the most cited gastrointestinal oncologists in Asia and the global principal investigator of the TOPAZ-1 trial that changed the first-line treatment landscape for advanced biliary tract cancer.

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Global Leader in Biliary Tract Cancer
Lead investigator of the TOPAZ-1 Phase III trial (685 patients, 17 countries), which established durvalumab plus chemotherapy as a new first-line standard for advanced biliary tract cancer.
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Exceptional Research Output
Over 450 peer-reviewed publications and a Scopus h-index of 78, reflecting deep expertise in immunotherapy, targeted therapy, and drug-development clinical trials for GI cancers.
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FGFR & HER2-Directed Therapy Expertise
Active research in FGFR-targeted therapy, HER2-directed agents, and antibody-drug conjugates for biliary tract and pancreatic cancers — areas that represent important options for patients with molecularly selected tumours.
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International Patient Support
SNUH provides a dedicated International Healthcare Center. CancerFax can facilitate report review, case preparation, and consultation coordination for patients travelling from overseas.
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Areas of Specialisation

Expert in gastrointestinal oncology, biliary tract cancer, and clinical drug development

Prof. Oh's clinical and research focus spans the full spectrum of gastrointestinal malignancies, with a particular emphasis on biliary tract cancer (cholangiocarcinoma and gallbladder cancer), pancreatic cancer, gastric cancer, and neuroendocrine tumours. She is internationally recognised for pioneering immunotherapy and targeted therapy approaches in these cancers.

Treatment Specialities

Biliary Tract Cancer

Advanced and recurrent biliary tract cancer including intrahepatic, extrahepatic cholangiocarcinoma, and gallbladder cancer.

starsImmunotherapy for Biliary Tract Cancer
  • arrow_rightDurvalumab plus gemcitabine and cisplatin (first-line, TOPAZ-1 regimen)
  • arrow_rightCheckpoint inhibitor therapy for eligible patients
  • arrow_rightBiomarker-driven patient selection for immunotherapy
starsFGFR-Directed Targeted Therapy
  • arrow_rightFGFR2 fusion and mutation-directed therapy for cholangiocarcinoma
  • arrow_rightMolecular profiling to guide FGFR inhibitor eligibility
  • arrow_rightIntegration with chemotherapy backbone regimens
starsHER2-Directed and Antibody-Drug Conjugate Therapy
  • arrow_rightHER2-expressing biliary tract cancer treatment approaches
  • arrow_rightAntibody-drug conjugate protocols under clinical investigation
  • arrow_rightTrastuzumab deruxtecan and related agents for selected cases

Pancreatic & Gastric Cancer

Systemic therapy for pancreatic cancer, gastric cancer, colorectal cancer, and neuroendocrine tumours.

starsPancreatic Cancer Systemic Therapy
  • arrow_rightGemcitabine-based and FOLFIRINOX combination regimens
  • arrow_rightTargeted therapy evaluation for molecularly selected pancreatic cancers
  • arrow_rightParticipation in clinical trials for advanced pancreatic cancer
starsGastric and Gastrointestinal Cancers
  • arrow_rightChemotherapy and immunotherapy combinations for advanced gastric cancer
  • arrow_rightFOLFOX and related regimens for colorectal and gastric cancers
  • arrow_rightClinical trial access for eligible GI cancer patients
starsNeuroendocrine Tumours
  • arrow_rightSystemic management of well-differentiated and poorly differentiated neuroendocrine tumours
  • arrow_rightSomatostatin analogue and targeted therapy approaches

Clinical Drug Development

Phase I–III clinical trials investigating novel systemic agents for gastrointestinal cancers.

starsClinical Trial Design and Leadership
  • arrow_rightGlobal principal investigator on Phase III trials including TOPAZ-1
  • arrow_rightDrug-development clinical research in GI oncology
  • arrow_rightNovel agent and combination regimen evaluation
Clinical Focus Areas
check_circleBiliary Tract Cancer (Cholangiocarcinoma)
check_circlePancreatic Cancer
check_circleGastric Cancer
check_circleNeuroendocrine Tumours
check_circleFGFR-Targeted Therapy
check_circleImmunotherapy in GI Cancers
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Procedures & Treatment Approaches

Systemic oncology, clinical trials, and molecular tumour profiling

Prof. Oh provides expert systemic oncology care for gastrointestinal malignancies, including chemotherapy, immunotherapy, and targeted therapy. Her clinical practice is closely integrated with her ongoing drug-development research.

Systemic Cancer Treatment

Medical Oncology

Chemotherapy and combination regimens for biliary tract, pancreatic, gastric, and colorectal cancers.

Chemotherapy Regimens
arrow_rightGemcitabine plus cisplatin for biliary tract cancer
arrow_rightFOLFOX for colorectal and gastric cancers
arrow_rightGemcitabine-based regimens for pancreatic cancer

Immunotherapy

Targeted Therapy

Checkpoint inhibitor therapy and immune-oncology combinations for GI malignancies.

Immune Checkpoint Inhibitors
arrow_rightDurvalumab plus chemotherapy for advanced biliary tract cancer (TOPAZ-1 regimen)
arrow_rightPD-1 and PD-L1 inhibitor combinations for eligible GI cancer patients
arrow_rightBiomarker-driven patient selection for immunotherapy eligibility

Targeted & Molecular Therapy

Targeted Therapy

Molecularly guided targeted therapy including FGFR inhibitors and HER2-directed agents.

Targeted Therapy Options
arrow_rightFGFR2-directed therapy for cholangiocarcinoma with FGFR alterations
arrow_rightHER2-directed therapy for HER2-expressing biliary tract and pancreatic cancers
arrow_rightIDH1-inhibitor therapy for IDH1-mutated cholangiocarcinoma
arrow_rightAntibody-drug conjugates including trastuzumab deruxtecan in selected cases

Molecular Diagnostics & Staging

Diagnosis

Comprehensive molecular profiling to guide personalised treatment decisions.

Biomarker and Molecular Testing
arrow_rightNext-generation sequencing for FGFR, IDH1, HER2, KRAS, and other actionable alterations
arrow_rightPD-L1 expression testing and MMR/MSI status assessment
arrow_rightImaging-based staging with CT, MRI, and PET-CT for treatment planning

Clinical Trials & Drug Development

Complex Disease

Access to Phase I–III investigational trials for gastrointestinal cancers.

Trial Participation
arrow_rightEligibility assessment for open clinical trials in biliary tract and pancreatic cancers
arrow_rightNovel agent evaluation for patients with limited standard-of-care options
arrow_rightGlobal clinical trial network involvement at SNUH

Second Opinion Consultations

Second Opinion

Expert independent review of pathology, molecular profiling, and treatment plans.

Case Review
arrow_rightReview of pathology, molecular profiling, and imaging for biliary and pancreatic cancers
arrow_rightAssessment of alternative systemic therapy and clinical trial options
arrow_rightWritten oncology opinion for patients seeking an independent expert view
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Research & Publications

Over 450 peer-reviewed publications and landmark Phase III trial leadership

Prof. Oh is one of the most prolific oncology researchers in Asia, with an h-index of 78 (Scopus) and over 37,000 citations. Her work has directly shaped global treatment guidelines for advanced biliary tract cancer.

Landmark Clinical Trial
arrow_rightOverall lead investigator — TOPAZ-1 global Phase III trial: durvalumab plus gemcitabine and cisplatin versus chemotherapy alone in advanced biliary tract cancer (685 patients, 17 countries)
arrow_rightTOPAZ-1 demonstrated improved overall survival with the durvalumab combination and established a new first-line treatment paradigm for advanced biliary tract cancer
Research Focus Areas
arrow_rightImmunotherapy combinations in advanced biliary tract cancer and cholangiocarcinoma
arrow_rightFGFR2-directed therapy and molecular selection in intrahepatic cholangiocarcinoma
arrow_rightHER2-directed therapy and antibody-drug conjugates (trastuzumab deruxtecan) in biliary tract and pancreatic cancers
arrow_rightIDH1-inhibitor therapy for IDH1-mutated biliary tract cancers
arrow_rightDrug-development clinical trials in gastric cancer, pancreatic cancer, and neuroendocrine tumours
Academic Profile
arrow_right456 research outputs including 431 journal articles and 19 review articles (Seoul National University profile)
arrow_right37,517 total citations; Scopus h-index 78
arrow_rightKey research topics: overall survival, biliary tract cancer, progression-free survival, cisplatin, gemcitabine, neoplasms
Clinical Trial Access

Prof. Oh's active involvement in global clinical trials means eligible patients may access investigational treatments at SNUH. CancerFax can help assess eligibility and support case submission.

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Education & Training

Prof. Oh completed her full medical training at Seoul National University College of Medicine, progressing from her undergraduate medical degree through to a doctoral degree in the same institution.

Undergraduate
MD (Medical Degree)
Seoul National University College of Medicine
1991 – 1997
Postgraduate
MS (Master of Science)
Seoul National University College of Medicine
2000 – 2002
Doctoral
PhD
Seoul National University College of Medicine
2002 – 2004
Doctoral research in oncology, building on her clinical training and establishing her research pathway in cancer therapeutics.
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Clinical Experience

Prof. Oh has spent her career at Seoul National University Hospital, one of South Korea's foremost academic medical centres, where she has built an internationally recognised clinical and research programme in gastrointestinal oncology.

Professor of Medical Oncology
Seoul National University Hospital
Department of Hemato-Oncology & Medical Oncology Center
check_circleAdvanced Biliary Tract Cancer — global Phase III trial lead (TOPAZ-1)
check_circlePancreatic and Gastric Cancer Systemic Therapy
check_circleImmunotherapy and Targeted Therapy in GI Cancers
check_circleFGFR and HER2-Directed Drug Development
check_circlePhase I–III Clinical Drug Development Research
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Languages & International

Prof. Oh conducts consultations in the following languages.

🇬🇧English
🇰🇷Korean
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients requiring consultation in languages other than English or Korean.

CancerFax can coordinate professional medical interpreter support for patients consulting in other languages.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Do-Youn Oh

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Do-Youn Oh's team — with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history — prepared as a structured clinical summary for Dr. Do-Youn Oh's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Do-Youn Oh before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Do-Youn Oh's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Do-Youn Oh's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Do-Youn Oh's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Prof. Do-Youn Oh

Prof. Oh specialises in gastrointestinal malignancies, with a particular focus on biliary tract cancer (including intrahepatic and extrahepatic cholangiocarcinoma and gallbladder cancer), pancreatic cancer, gastric cancer, colorectal cancer, and neuroendocrine tumours. She is internationally recognised as a leading expert in biliary tract cancer.

Prof. Oh is a Professor of Medical Oncology at Seoul National University Hospital (SNUH) in Seoul, South Korea, one of the country's leading academic medical centres. She works within the Department of Hemato-Oncology and the Medical Oncology Center at SNUH.

TOPAZ-1 was a global Phase III clinical trial that evaluated durvalumab (an immunotherapy agent) combined with gemcitabine and cisplatin chemotherapy against chemotherapy alone as a first-line treatment for advanced or recurrent biliary tract cancer. The trial enrolled 685 patients across 17 countries and demonstrated improved overall survival with the durvalumab combination. Prof. Oh served as the overall lead investigator of the trial, and its results helped establish a new treatment standard for advanced biliary tract cancer.

Seoul National University Hospital operates a dedicated International Healthcare Center that supports international patients with appointments, language assistance, and billing guidance. CancerFax can coordinate medical-report review and consultation preparation for international patients seeking an opinion from Prof. Oh, subject to hospital availability and case acceptance.

Submit your medical reports through CancerFax using the Send Your Reports button. The CancerFax team will review your documents, prepare a structured case summary, and coordinate the next steps with SNUH on your behalf, subject to availability. For a second opinion, please include pathology reports, molecular profiling results, imaging, and your current treatment history.

Yes. FGFR-directed therapy is one of Prof. Oh's recognised areas of clinical and research expertise. For patients with intrahepatic cholangiocarcinoma and FGFR2 fusions or mutations, FGFR inhibitors may represent an important treatment option. Eligibility depends on molecular profiling results, which can be reviewed as part of a consultation or second-opinion process facilitated through CancerFax.

Yes. SNUH lists clinical trials and clinical drug-development research among Prof. Oh's specialty areas, and she has led and participated in multiple global oncology trials. Patients who may be eligible for open trials at SNUH can request an assessment through CancerFax as part of the consultation coordination process.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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