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Byoung Chul Cho
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schoolMD, PhD โ€“ Thoracic Oncology

Dr.ย Byoung Chulย Cho

MD, PhD

Professor, Medical Oncology

corporate_fareYonsei Cancer Center / Severance Hospital, Seoul

check_circleEGFR Exon20 Lung Cancer
check_circleAmivantamab & Lazertinib
check_circleTargeted Therapy
check_circleClinical Trials
INSTITUTION
corporate_fareYonsei Cancer Center / Severance Hospital
DEPARTMENT
scienceMedical Oncology โ€“ Thoracic Oncology
SPECIALTY
medical_servicesLung Cancer, EGFR Exon20, Amivantamab, Targeted Therapy
LOCATION
location_onSeoul, South Korea
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
person

Byoung Chul Cho

MD, PhD

Prof. Byoung Chul Cho is a Professor of Medical Oncology and a leading thoracic oncology specialist at Yonsei Cancer Center / Severance Hospital in Seoul, South Korea. He is internationally recognised for his work in EGFR-mutated non-small cell lung cancer (NSCLC), with particular focus on EGFR exon 20 insertion mutations and the development of bispecific antibody-based treatment strategies.

With over 20 years of clinical and research experience, Prof. Cho has been a principal investigator in several landmark global lung cancer trials, including pivotal studies evaluating amivantamab and lazertinib in EGFR-driven NSCLC. His clinical approach integrates comprehensive molecular profiling, biomarker-directed therapy, and access to international clinical trials for patients with advanced or treatment-resistant lung cancer. He manages a wide spectrum of thoracic malignancies, including EGFR-mutated NSCLC, EGFR exon 20 insertion NSCLC, and thymic tumours. Prof. Cho is widely cited in the global thoracic oncology community and his research has helped shape treatment guidelines for molecularly defined lung cancer subtypes.

workspace_premium20+Years Experience
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Visiting Days
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International Patients

CancerFax can coordinate medical report review and consultation support for international patients seeking an expert opinion from Prof. Byoung Chul Cho at Yonsei Cancer Center / Severance Hospital.

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Why Consider Prof. Byoung Chul Cho?

Prof. Cho is one of the most recognised lung cancer specialists globally, with particular expertise in molecularly driven NSCLC and access to cutting-edge treatments and clinical trials at one of South Korea's leading cancer hospitals.

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Global Leader in EGFR Exon20 Research
Prof. Cho is internationally known for his contributions to EGFR exon 20 insertion NSCLC research, including pivotal trials involving amivantamab โ€“ a targeted EGFR-MET bispecific antibody โ€“ and lazertinib combination strategies.
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Principal Investigator in Major Lung Cancer Trials
He has served as a PI in landmark international studies for advanced EGFR-mutated NSCLC, giving patients at his centre access to investigational and newly approved treatment options unavailable at many other institutions.
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20+ Years of Thoracic Oncology Experience
With over two decades of clinical and translational oncology experience, Prof. Cho brings deep expertise in treating complex, metastatic, and treatment-resistant lung cancer using precision medicine approaches.
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International Patient Support at Severance Hospital
Yonsei Cancer Center / Severance Hospital has a dedicated international patient pathway. CancerFax can assist with report preparation, case submission, and coordination for overseas patients.
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Areas of Specialisation

Precision lung cancer care guided by molecular profiling and clinical evidence

Prof. Byoung Chul Cho specialises in thoracic oncology with a focus on EGFR-mutated non-small cell lung cancer, EGFR exon 20 insertion NSCLC, and novel targeted treatment strategies including bispecific antibody combinations.

Treatment Specialties

EGFR-Mutated NSCLC

Targeted treatment strategies for patients with EGFR-driven non-small cell lung cancer, including first-line, later-line, and resistance settings.

starsEGFR Exon 20 Insertion NSCLC
  • arrow_rightAmivantamab-based treatment for EGFR exon20 insertion mutations
  • arrow_rightMolecular characterisation and treatment planning for this difficult-to-treat subtype
  • arrow_rightManagement of patients with limited response to older EGFR inhibitors
starsEGFR-Mutated Advanced NSCLC
  • arrow_rightLazertinib and amivantamab combination strategies
  • arrow_rightTreatment planning after resistance to EGFR tyrosine kinase inhibitors
  • arrow_rightBiomarker-guided selection of targeted versus immunotherapy approaches

Targeted Therapy & Immunotherapy

Systematic personalised treatment selection based on comprehensive molecular testing for lung cancer and related thoracic malignancies.

starsTargeted Therapy for Lung Cancer
  • arrow_rightEGFR, ALK, ROS1, MET, RET, NTRK, HER2, BRAF, KRAS-directed therapy
  • arrow_rightMolecular profiling including NGS and ctDNA to guide treatment selection
  • arrow_rightCombination antibody-based therapies including EGFR-MET bispecific agents
starsImmunotherapy for Lung Cancer
  • arrow_rightPD-1 and PD-L1 checkpoint inhibitor selection based on TMB and PD-L1 expression
  • arrow_rightChemoimmunotherapy combinations for suitable patients
  • arrow_rightEvaluation of immunotherapy sequencing after targeted therapy

Thoracic Oncology โ€“ Broader Scope

Management of thymic tumours and other rare or complex thoracic malignancies alongside advanced lung cancer.

starsThymic Tumours & Rare Thoracic Cancers
  • arrow_rightMultidisciplinary evaluation and systemic treatment planning for thymic carcinoma and thymoma
  • arrow_rightClinical trial access for rare thoracic malignancies where standard options are limited
Clinical Focus Areas
check_circleEGFR Exon 20 Insertion NSCLC
check_circleEGFR-Mutated Advanced Lung Cancer
check_circleAmivantamab & Lazertinib Strategies
check_circleTargeted Therapy โ€“ Lung Cancer
check_circleImmunotherapy for NSCLC
check_circleThymic Tumours
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Procedures & Treatment Approaches

Evidence-based systemic and targeted treatment for advanced lung cancer

Prof. Cho's clinical practice covers the full range of systemic treatment options for thoracic malignancies, with a strong emphasis on molecularly guided therapy, clinical trials, and management of treatment-resistant disease.

Targeted Therapy for EGFR-Mutated NSCLC

Targeted Therapy

Precision targeting of EGFR-driven lung cancers using approved and investigational agents, including combination strategies for exon 20 insertions and resistance settings.

EGFR-Directed Treatment Options
arrow_rightAmivantamab (EGFR-MET bispecific antibody) for eligible patients
arrow_rightLazertinib (third-generation EGFR TKI) alone or in combination
arrow_rightOsimertinib and other EGFR TKIs for selected mutation profiles
arrow_rightPost-resistance treatment planning with repeat biopsy or liquid biopsy guidance

Medical Oncology for Lung Cancer

Medical Oncology

Comprehensive systemic treatment planning for advanced and metastatic non-small cell and small cell lung cancer.

Systemic Treatment Options
arrow_rightImmunotherapy: pembrolizumab, nivolumab, atezolizumab based on biomarker results
arrow_rightChemotherapy regimens including carboplatin-based combinations
arrow_rightChemoimmunotherapy combinations for eligible advanced NSCLC patients
arrow_rightALK, ROS1, MET, RET, NTRK-directed agents where molecular testing supports use

Clinical Trial Access

Complex Disease

Evaluation of eligibility for international lung cancer clinical trials, particularly in EGFR-driven and molecularly defined NSCLC.

Trial Eligibility & Enrolment
arrow_rightReview of molecular profile against open trial criteria
arrow_rightAccess to early-phase and registration trials in EGFR-mutated NSCLC
arrow_rightTrial options for patients who have exhausted standard treatment lines

Molecular Diagnosis & Treatment Planning

Diagnosis

Comprehensive biomarker evaluation to guide precise treatment decisions for lung cancer patients.

Diagnostic Workup
arrow_rightNGS panel testing to identify actionable genomic alterations
arrow_rightPD-L1 expression and TMB assessment for immunotherapy decisions
arrow_rightctDNA / liquid biopsy for treatment monitoring and resistance detection
arrow_rightImaging review: CT chest/abdomen, PET-CT, brain MRI

Second Opinion โ€“ Lung Cancer

Second Opinion

International second opinions for patients with advanced or complex lung cancer seeking expert review of their diagnosis and treatment plan.

Second Opinion Process
arrow_rightReview of pathology, molecular testing, and prior treatment history
arrow_rightIndependent assessment of treatment adequacy and available alternatives
arrow_rightStructured written report or consultation summary for referring physicians
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Research & Publications

Internationally cited contributions to EGFR-mutated lung cancer and precision thoracic oncology

Prof. Byoung Chul Cho is among the most recognised clinical researchers in thoracic oncology globally, with key contributions to EGFR exon 20 insertion NSCLC research, amivantamab development, lazertinib clinical trials, and precision oncology in lung cancer.

Key Research Areas
arrow_rightEGFR exon 20 insertion NSCLC โ€“ biology, treatment response, and novel targeted agents
arrow_rightAmivantamab (JNJ-61186372) โ€“ EGFR-MET bispecific antibody clinical development
arrow_rightLazertinib โ€“ third-generation EGFR TKI in first-line and resistance settings
arrow_rightAmivantamab plus lazertinib combination strategies in EGFR-mutated advanced NSCLC
arrow_rightResistance mechanisms after first- and third-generation EGFR tyrosine kinase inhibitors
arrow_rightBiomarker-guided treatment selection and precision oncology in Asian lung cancer populations
Selected Clinical Trial Involvement
arrow_rightCHRYSALIS trial โ€“ amivantamab in EGFR exon 20 insertion NSCLC (principal investigator / key contributor)
arrow_rightMARIPOSA trial โ€“ amivantamab plus lazertinib vs osimertinib in first-line EGFR-mutated NSCLC
arrow_rightPAPILLON trial โ€“ amivantamab plus carboplatin-pemetrexed in EGFR exon 20 insertion NSCLC
arrow_rightLASER301 trial โ€“ lazertinib as first-line EGFR TKI in EGFR-mutated advanced NSCLC
arrow_rightMultiple early-phase studies at Yonsei Cancer Center in EGFR-driven and molecularly defined NSCLC
Full Publication Profile

Prof. Cho's complete list of peer-reviewed publications is available via PubMed and Google Scholar. Patients and referring physicians may contact CancerFax for a case-specific research summary.

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Education & Training

Prof. Cho completed his medical training at Yonsei University, one of South Korea's most prestigious academic medical institutions, and pursued advanced research training in the United States.

Undergraduate
MD (Medicine)
Yonsei University College of Medicine, Seoul, South Korea
1990s
Postgraduate
PhD (Medical Sciences)
Yonsei University, Seoul, South Korea
Advanced Research Training
Research Fellowship / Advanced Training
United States (institution to be confirmed)
Academic Appointment
Professor of Medical Oncology
Yonsei University College of Medicine / Yonsei Cancer Center
work_history

Clinical Experience

Prof. Byoung Chul Cho has spent his career at Yonsei Cancer Center / Severance Hospital, building one of South Korea's most internationally recognised thoracic oncology programmes over more than 20 years of clinical and research practice.

Professor, Medical Oncology
Yonsei Cancer Center / Severance Hospital
Division of Medical Oncology, Yonsei University Health System
check_circleEGFR-mutated NSCLC and exon 20 insertion treatment
check_circlePrincipal investigator in global lung cancer trials
check_circleAmivantamab and lazertinib clinical development
check_circleMolecularly guided treatment for advanced and metastatic lung cancer
check_circleMultidisciplinary thoracic tumour board at Severance Hospital
check_circleInternational patient consultation and second opinion
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Languages & International

Prof. Cho consults in the following languages.

๐Ÿ‡ฌ๐Ÿ‡งEnglish
๐Ÿ‡ฐ๐Ÿ‡ทKorean
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients requiring assistance in languages other than English or Korean.

CancerFax can coordinate professional medical interpreter support for patients consulting in other languages.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Byoung Chul Cho

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Byoung Chul Cho's team โ€” with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history โ€” prepared as a structured clinical summary for Dr. Byoung Chul Cho's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Byoung Chul Cho before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Byoung Chul Cho's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Byoung Chul Cho's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Byoung Chul Cho's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Prof. Byoung Chul Cho

Prof. Byoung Chul Cho is a Professor of Medical Oncology and thoracic oncology specialist at Yonsei Cancer Center / Severance Hospital in Seoul, South Korea. He is internationally recognised for his work in EGFR-mutated non-small cell lung cancer, EGFR exon 20 insertion NSCLC, and the clinical development of amivantamab and lazertinib.

Prof. Cho is best known for his contributions to EGFR exon 20 insertion lung cancer research and his role in landmark clinical trials involving amivantamab (an EGFR-MET bispecific antibody) and lazertinib. His work has helped establish new treatment standards for patients with EGFR-driven NSCLC, including those who have progressed after earlier EGFR inhibitors.

Yes. EGFR exon 20 insertion NSCLC is one of Prof. Cho's primary areas of expertise. He has been closely involved in clinical trials evaluating amivantamab and other agents designed specifically for this molecularly distinct subtype, which historically had limited response to older EGFR tyrosine kinase inhibitors.

Prof. Cho is based at Yonsei Cancer Center / Severance Hospital, part of the Yonsei University Health System in Seoul, South Korea. Severance Hospital is one of South Korea's leading academic medical centres and has a structured international patient programme.

Yes. International patients with lung cancer, EGFR-mutated NSCLC, or EGFR exon 20 insertion mutations may seek consultation at Yonsei Cancer Center / Severance Hospital. CancerFax can help coordinate medical report review, case preparation, and appointment planning, subject to hospital availability and case acceptance.

Submit your medical reports through CancerFax. The CancerFax team will review your documents, prepare a structured case summary, and coordinate the next steps with Yonsei Cancer Center / Severance Hospital. Relevant documents include pathology reports, molecular or NGS test results, PET-CT and imaging reports, and previous treatment records.

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Free case review ยท No commitment ยท Response within 24 hours ยท Available in 12+ languages

Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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