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Brian Druker
verifiedCancerFax Verified
schoolM.D. Β· UCSD 1981

Dr.Β BrianΒ Druker

M.D., ABIM Board Certified

Professor of Medicine & Leukemia Specialist

corporate_fareOHSU Knight Cancer Institute, Portland, Oregon

check_circleChronic Myeloid Leukaemia
check_circleTargeted Therapy & TKIs
check_circleImatinib / Gleevec Pioneer
check_circleCancer Early Detection
INSTITUTION
corporate_fareOHSU Knight Cancer Institute
DEPARTMENT
scienceHematology / Medical Oncology
SPECIALTY
medical_servicesCML Β· Targeted Therapy Β· Precision Oncology
LOCATION
location_onPortland, Oregon, USA
INTERNATIONAL PATIENTS
publicInternational Patients Welcome
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Brian Druker

M.D., ABIM Board Certified

Dr. Brian J. Druker is a physician-scientist and internationally recognised leukemia specialist at the OHSU Knight Cancer Institute in Portland, Oregon. He is best known for his pivotal role in developing imatinib (Gleevec), a molecularly targeted therapy that transformed chronic myeloid leukaemia from a historically fatal diagnosis into a manageable condition for the majority of patients.

Dr. Druker received his M.D. from the University of California San Diego in 1981, followed by residency at Barnes Hospital, Washington University, and fellowship training in medical oncology at Dana-Farber Cancer Institute, Harvard Medical School. He has been associated with OHSU since the 1990s, serving as Director of the OHSU Cancer Institute and Knight Cancer Institute from 2007, and helping lead the $1 billion Knight Cancer Challenge that enabled major research expansion, including the Cancer Early Detection Advanced Research Center. His current clinical and research focus encompasses chronic myeloid leukaemia, BCR-ABL biology, tyrosine kinase inhibition, acute myeloid leukaemia, and integrated patient-centred cancer care. With more than 40 years of medical and research experience and an h-index of 129 from over 88,000 Scopus citations, Dr. Druker is among the most influential oncologists of his generation.

workspace_premium44+Years Experience
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Visiting Days
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International Patients

CancerFax can coordinate medical-report review and consultation support for international patients seeking an opinion from Dr. Druker at OHSU Knight Cancer Institute, subject to hospital availability and case acceptance.

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Why Consider Dr. Brian Druker?

Dr. Druker helped establish the modern era of precision cancer medicine and remains one of the foremost authorities on chronic myeloid leukaemia and targeted therapy.

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Pioneer of Precision Oncology
Dr. Druker's landmark work on imatinib/Gleevec proved that a cancer-driving molecular defect could be selectively targeted, transforming CML treatment globally and inspiring an entire generation of targeted therapies.
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Over 40 Years of Leukemia Expertise
With his M.D. awarded in 1981 and decades of BCR-ABL research, Dr. Druker brings unmatched depth of experience in chronic and acute myeloid leukaemia to every clinical interaction.
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Active Research Leadership
He has contributed to more than 547 peer-reviewed publications with over 88,000 Scopus citations and has helped lead the Beat AML master trial β€” a national initiative to find effective therapies for acute myeloid leukaemia.
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Integrated, Patient-Centred Care
Dr. Druker advocates for a comprehensive cancer care model that includes clinical trials, genetic counselling, psychological support, symptom management, and survivorship services alongside active treatment.
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Areas of Specialisation

Chronic myeloid leukaemia, BCR-ABL targeted therapy, precision oncology, and leukemia clinical research

Dr. Druker's clinical and research expertise is centred on the molecular mechanisms driving leukaemia and on translating that knowledge into more effective, less toxic treatments for patients.

Clinical Specialties

Chronic Myeloid Leukaemia (CML)

Comprehensive management of CML across all phases, with deep expertise in BCR-ABL biology and tyrosine kinase inhibitor therapy.

starsBCR-ABL Targeted Therapy
  • arrow_rightImatinib (Gleevec) and second-generation TKI treatment planning
  • arrow_rightMolecular response monitoring and treatment optimisation
  • arrow_rightManagement of TKI resistance and treatment-free remission assessment
starsCML Clinical Evaluation
  • arrow_rightCytogenetic and molecular assessment of Philadelphia chromosome-positive disease
  • arrow_rightRisk stratification and phase assessment (chronic, accelerated, blast)
  • arrow_rightLong-term follow-up and survivorship planning for CML patients

Precision Oncology & Targeted Therapy

Molecularly guided cancer treatment based on the specific genetic and protein drivers of each patient's cancer.

starsTyrosine Kinase Inhibitor Therapy
  • arrow_rightSelection and sequencing of TKIs based on molecular profiling
  • arrow_rightMonitoring of response and management of drug-related adverse effects
  • arrow_rightGuidance on novel and emerging kinase inhibitors in clinical trials
starsMolecularly Guided Cancer Care
  • arrow_rightBiomarker-driven treatment planning across haematological malignancies
  • arrow_rightIntegration of genomic data into clinical decision-making
  • arrow_rightReferral and access to relevant clinical trial protocols

Leukemia Research & Clinical Trials

Active involvement in clinical research addressing unmet needs in CML, AML, and related haematological cancers.

starsAcute Myeloid Leukaemia (AML)
  • arrow_rightResearch and trial leadership through the Beat AML national initiative
  • arrow_rightEvaluation of novel targeted agents for AML subtypes
  • arrow_rightCollaborative care model connecting AML patients to active trials
starsCancer Early Detection
  • arrow_rightLeadership of the Cancer Early Detection Advanced Research Center (CEDAR) at OHSU
  • arrow_rightExploration of blood-based and molecular biomarker strategies for early-stage detection
Clinical Focus Areas
check_circleChronic Myeloid Leukaemia
check_circleBCR-ABL & Tyrosine Kinase Biology
check_circleImatinib / Gleevec Therapy
check_circleAcute Myeloid Leukaemia Research
check_circlePrecision Oncology
check_circleCancer Early Detection
medical_services

Clinical Services & Treatment Approaches

Medical oncology, targeted therapy, and leukemia care at OHSU Knight Cancer Institute

Dr. Druker's clinical practice focuses on the medical management of haematological malignancies, with particular expertise in CML and molecularly targeted therapies.

Chronic Myeloid Leukaemia Management

Medical Oncology

Comprehensive CML care from diagnosis through long-term molecular remission.

CML Treatment Approaches
arrow_rightFirst-line and subsequent TKI therapy selection and initiation
arrow_rightMolecular monitoring (BCR-ABL PCR) and response assessment
arrow_rightTreatment-free remission evaluation for eligible patients
arrow_rightManagement of blast-phase CML and TKI-resistant disease

Targeted & Molecularly Guided Therapy

Targeted Therapy

Precision treatment planning based on the molecular and genetic profile of each patient's cancer.

Targeted Therapy Protocols
arrow_rightBCR-ABL1 kinase inhibitor therapy (imatinib, dasatinib, nilotinib, and others)
arrow_rightBiomarker-driven treatment selection for haematological malignancies
arrow_rightMonitoring and adjustment of targeted therapy regimens over time

Leukemia Diagnosis & Evaluation

Diagnosis

Complete haematological and molecular evaluation to accurately characterise leukaemia and guide treatment planning.

Diagnostic Work-Up
arrow_rightCytogenetic and FISH analysis for Philadelphia chromosome detection
arrow_rightQuantitative PCR for BCR-ABL1 transcript monitoring
arrow_rightBone marrow evaluation and haematopathology review
arrow_rightMolecular profiling for kinase domain mutations

Second Opinion β€” Leukaemia & Haematological Cancers

Second Opinion

Independent expert review for patients with CML, AML, and related haematological diagnoses.

Second Opinion Process
arrow_rightReview of bone marrow biopsy and cytogenetic reports
arrow_rightAssessment of current treatment plan and molecular response data
arrow_rightEvaluation of clinical trial eligibility and novel therapy access
arrow_rightWritten oncology opinion covering diagnosis, treatment, and prognosis
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Research & Publications

Landmark contributions to leukemia therapy, precision oncology, and cancer early detection

Dr. Druker is one of the most cited physician-scientists in oncology, with more than 547 publications, over 88,000 Scopus citations, and an h-index of 129 as listed on the OHSU Elsevier Pure profile.

Landmark Publications
arrow_rightEfficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia β€” New England Journal of Medicine, 2001 (Druker BJ et al.)
arrow_rightFive-year follow-up of patients receiving imatinib for chronic myeloid leukemia β€” New England Journal of Medicine (Druker BJ et al.; imatinib long-term outcomes)
arrow_rightActivity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome β€” New England Journal of Medicine, 2001
Clinical Trial Leadership
arrow_rightBeat AML Master Trial β€” co-leadership of a national AML precision medicine initiative coordinating academic centres, biotech partners, and the FDA to match patients to targeted therapies based on genomic profiling
arrow_rightOHSU Cancer Early Detection Advanced Research Center (CEDAR) β€” institutional leadership in blood-based biomarker and early-detection research
Awards & Recognition
arrow_rightLasker-DeBakey Clinical Medical Research Award
arrow_rightJapan Prize in Healthcare and Medical Technology
arrow_rightTang Prize in Biopharmaceutical Science
arrow_rightSjΓΆberg Prize, Royal Swedish Academy of Sciences
arrow_rightWarren Alpert Prize, Harvard Medical School
arrow_rightPrince Mahidol Award for outstanding achievements in medicine
arrow_rightElected: National Academy of Medicine, National Academy of Sciences, American Academy of Arts and Sciences
Research Profile

A full publication list is available via the OHSU Elsevier Pure research profile. Patients with CML or AML may be eligible for active clinical trials at OHSU Knight Cancer Institute.

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Education & Training

Dr. Druker trained at leading U.S. medical institutions, completing his M.D. at UCSD followed by residency and fellowship at Washington University and Harvard Medical School.

Medical Degree
M.D.
University of California San Diego (UCSD), School of Medicine
1977 – 1981
Doctor of Medicine degree from UCSD.
Residency
Residency in Internal Medicine
Barnes Hospital, Washington University in St. Louis
1981 – 1984
Clinical residency training in internal medicine. Board certified by the American Board of Internal Medicine in 1984.
Fellowship
Fellowship in Medical Oncology
Dana-Farber Cancer Institute, Harvard Medical School, Boston
1984 – 1987
Fellowship training in medical oncology with a focus on haematological malignancies and cancer biology.
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Clinical Experience

Dr. Druker has been associated with OHSU for more than three decades, building the Knight Cancer Institute into a globally recognised cancer research and treatment centre.

Professor of Medicine, Division of Hematology/Medical Oncology
OHSU Knight Cancer Institute
Oregon Health & Science University School of Medicine
check_circleChronic Myeloid Leukaemia β€” clinical management and research
check_circleBCR-ABL tyrosine kinase inhibitor therapy
check_circleAcute Myeloid Leukaemia β€” Beat AML trial leadership
check_circleCancer Early Detection Research (CEDAR)
check_circleInstitutional leadership β€” Knight Cancer Institute from 2007
check_circleHoward Hughes Medical Institute Investigator (2002 – 2019)
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Languages & International

Dr. Druker consults in the following language.

πŸ‡ΊπŸ‡ΈEnglish
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients consulting with Dr. Druker at OHSU.

CancerFax can coordinate professional medical interpreter support for international patients when required.

support_agentHow CancerFax Helps

How CancerFax Helps You Access Dr. Brian Druker

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Brian Druker's team β€” with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history β€” prepared as a structured clinical summary for Dr. Brian Druker's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Brian Druker before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Brian Druker's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Brian Druker's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Brian Druker's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Dr. Brian Druker

Dr. Druker is best known for his pioneering role in the development and clinical advancement of imatinib (Gleevec), a targeted therapy for chronic myeloid leukaemia (CML). His work helped establish that a cancer driven by a specific molecular defect could be selectively targeted by a drug, transforming CML from a historically fatal diagnosis into a manageable condition for most patients and helping launch the modern era of precision cancer medicine.

Dr. Druker's verified clinical and research focus is chronic myeloid leukaemia (CML), including BCR-ABL-positive and Philadelphia chromosome-positive leukaemias. He is also involved in acute myeloid leukaemia (AML) research, including the Beat AML master trial, and cancer early detection research through the OHSU CEDAR centre.

Dr. Brian Druker is based at the OHSU Knight Cancer Institute at Oregon Health & Science University in Portland, Oregon, United States.

Submit your medical reports through CancerFax using the Send Your Reports button. The CancerFax team will review your documents, prepare the case for submission, and coordinate the next steps with OHSU Knight Cancer Institute, subject to availability and case acceptance.

A second-opinion request can be submitted through CancerFax with the patient's pathology reports, cytogenetics, molecular test results (BCR-ABL PCR), imaging, and treatment history. The final consultation format and availability depend on OHSU's scheduling and case-acceptance process.

CancerFax can coordinate report review and consultation support for international patients seeking an opinion from Dr. Druker at OHSU Knight Cancer Institute, subject to hospital availability and case acceptance. Please contact CancerFax to discuss your specific situation.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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