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Amit Dutt
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schoolPhD โ€“ ICGEB & University of Zurich

Dr.ย Amitย Dutt

PhD (ICGEB / Jamia Millia Islamia), PhD (University of Zurich)

Professor & Tata Innovation Fellow | Cancer Genomics Scientist

corporate_fareUniversity of Delhi South Campus; formerly ACTREC, Tata Memorial Centre

check_circleCancer Genomics
check_circlePrecision Oncology
check_circleNext-Generation Sequencing
check_circleShanti Swarup Bhatnagar Prize 2017
INSTITUTION
corporate_fareUniversity of Delhi South Campus / ACTREC, Tata Memorial Centre
DEPARTMENT
scienceDepartment of Genetics / Integrated Cancer Genomics
SPECIALTY
medical_servicesCancer Genomics, Precision Oncology, Functional Genomics, NGS
LOCATION
location_onNew Delhi / Mumbai, India
INTERNATIONAL PATIENTS
publicInternational Research Collaborations Welcome
person

Amit Dutt

PhD (ICGEB / Jamia Millia Islamia), PhD (University of Zurich)

Dr. Amit Dutt is a pioneering cancer genomics scientist and Professor at the Department of Genetics, University of Delhi South Campus, and a Tata Innovation Fellow. He is widely recognised as one of India's foremost researchers in integrated cancer genomics, precision oncology, next-generation sequencing, and cancer biomarker discovery.

Dr. Dutt holds two doctoral degrees โ€” in Plant Genetics from ICGEB / Jamia Millia Islamia, New Delhi, and in Developmental Biology from the University of Zurich, Switzerland. He completed postdoctoral training in cancer genomics at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, Boston. From 2010 to 2023/24, he led the Integrated Cancer Genomics laboratory (Dutt Lab) at ACTREC, Tata Memorial Centre as Principal Investigator / Scientific Officer G, where his team used advanced sequencing technologies to map somatic genetic alterations across Indian cancer cohorts spanning lung, breast, oral, cervical, gallbladder, and head and neck cancers. In 2017, Dr. Dutt received the Shanti Swarup Bhatnagar Prize for Medical Sciences โ€” India's highest science honour โ€” for cancer genomics work focused on interpretation, characterisation, and clinical translation of genomic discoveries.

workspace_premium20+Years Experience
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Visiting Days
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Research-Led Precision Oncology

Dr. Dutt is a PhD cancer genomics scientist, not a treating clinical oncologist. CancerFax profiles him as a precision oncology and genomics expert whose research supports molecular diagnostics, biomarker interpretation, and targeted therapy decision-making.

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Why Dr. Amit Dutt's Work Matters for Cancer Patients

Dr. Dutt's cancer genomics research directly supports modern precision oncology โ€” from molecular tumour profiling and NGS-based biomarker discovery to tools that help clinicians select targeted therapies for individual patients.

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Shanti Swarup Bhatnagar Prize โ€“ 2017
Recipient of India's most prestigious science award in Medical Sciences for cancer genomics research translating genomic discoveries into clinical insights.
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Pioneer of Indian Cancer Genomics
Led genomic profiling of approximately 1,000 Indian lung cancer samples at ACTREC, establishing EGFR and KRAS mutation landscape data relevant to targeted therapy decision-making in Indian patients.
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Developer of Precision Oncology Tools
Creator of HPVDetector (NGS-based HPV genome detection) and TMC-SNPdb / TMC-SNPdb 2.0, the first comprehensive Indian germline variant database supporting cancer genome interpretation.
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Broad Institute & Harvard-Trained Genomicist
Postdoctoral training at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute provides a global research foundation underpinning his work in India.
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Research Specialisations

Cancer genomics, functional oncology, and precision medicine tools for Indian cancer cohorts

Dr. Dutt's laboratory bridges laboratory science, computational biology, and translational oncology. His research generates genomic insights that support molecular diagnostics, targeted therapy selection, and biomarker development โ€” particularly for cancer types prevalent in India.

Research Focus Areas

Cancer Genomics & Somatic Mutation Profiling

Genome-wide characterisation of somatic alterations driving cancer initiation and progression.

starsWhole Exome & Genome Sequencing
  • arrow_rightSomatic mutation profiling across Indian cancer cohorts
  • arrow_rightIdentification of oncogenic drivers: EGFR, KRAS, FGFR, NOTCH pathways
  • arrow_rightStructural variant and gene fusion discovery
starsTranscriptome & Epigenome Analysis
  • arrow_rightRNA-seq and expression profiling of cancer samples
  • arrow_rightComputational pipelines for high-throughput sequencing datasets

Precision Oncology & Biomarker Discovery

Translating genomic findings into diagnostics, therapeutic targets, and biomarkers for clinical use.

starsTargeted Therapy Biomarker Research
  • arrow_rightEGFR mutation profiling to guide EGFR TKI therapy in lung cancer
  • arrow_rightHER2, CDK4/6, and hormone therapy resistance markers in breast cancer
  • arrow_rightMolecular tumour board research contributions
starsPathogen-Associated Cancer Research
  • arrow_rightHPV detection from NGS datasets using HPVDetector
  • arrow_rightMicrobial association studies in cervical and head and neck cancers

Functional Genomics & Experimental Oncology

Validating genomic discoveries through functional and experimental approaches.

starsCRISPR-Cas & shRNA Screening
  • arrow_rightGenome-wide pooled shRNA and CRISPR screens to identify cancer dependencies
  • arrow_rightFunctional validation of candidate driver genes
starsIn Vivo & Cell-Based Models
  • arrow_rightXenograft and orthotopic mouse models for functional validation
  • arrow_rightCell-based assays for therapeutic vulnerability characterisation
Cancer Types Studied
check_circleLung Cancer (NSCLC & SCLC)
check_circleBreast Cancer
check_circleOral & Head and Neck Cancer
check_circleCervical Cancer
check_circleGallbladder Cancer
check_circleRare and Under-Studied Cancers
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Research Methods & Scientific Approaches

Laboratory and computational approaches used in Dr. Dutt's cancer genomics programme

Dr. Dutt's research programme integrates next-generation sequencing, computational biology, and functional experimental approaches to characterise cancer genomes and identify clinically actionable findings.

Next-Generation Sequencing in Cancer Research

Diagnosis

Advanced sequencing technologies applied to human cancer samples to identify genomic alterations relevant to cancer diagnosis and targeted treatment.

Sequencing Approaches
arrow_rightWhole exome sequencing (WES) for somatic mutation profiling
arrow_rightWhole genome sequencing for structural variant discovery
arrow_rightRNA-seq for transcriptome and fusion gene analysis
arrow_rightLiquid biopsy and circulating tumour DNA research

Precision Oncology & Molecular Profiling

Targeted Therapy

Translational genomics research connecting cancer genome data to potential targeted therapy strategies.

Biomarker & Therapeutic Target Discovery
arrow_rightIdentification of actionable mutations for targeted therapy selection
arrow_rightEndocrine therapy resistance mechanisms in hormone receptor-positive breast cancer
arrow_rightCDKN1B / p27 loss-of-function and CDK4/6 inhibitor relevance

Computational Cancer Genomics

Complex Disease

Development and application of bioinformatics pipelines and databases for cancer genome interpretation.

Tools & Databases Developed
arrow_rightHPVDetector โ€“ automated HPV genome detection and annotation from NGS data
arrow_rightTMC-SNPdb / TMC-SNPdb 2.0 โ€“ Indian germline variant database for cancer genome interpretation
arrow_rightCustom pipelines for WES, WGS, and transcriptome data analysis

Second Opinion & Molecular Tumour Board Support

Second Opinion

Research contributions to molecular tumour board frameworks and precision oncology implementation.

Precision Oncology Research Applications
arrow_rightMolecular tumour board data and precision oncology implementation research
arrow_rightGenomic interpretation frameworks for treatment decision support
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Research & Publications

Peer-reviewed cancer genomics publications, tools, and academic contributions

Dr. Amit Dutt has published extensively in cancer genomics and translational oncology. His Google Scholar profile lists over 11,500 citations, an h-index of 41, and an i10-index of 69. A 2019 ACTREC CV listed 55 peer-reviewed publications at that time.

Selected Peer-Reviewed Publications
arrow_rightCDKN1B inactivation drives endocrine therapy resistance in HR+/HER2- breast cancer and may guide CDK4/6 inhibitor therapy โ€“ British Journal of Cancer, 2026
arrow_rightLung cancer genomics in Indian patients: EGFR and KRAS mutation profiling across ~1,000 samples โ€“ ACTREC / Dutt Lab
arrow_rightHPVDetector: a GUI-based automated tool for detecting and annotating HPV genomes from NGS datasets โ€“ Dutt Lab tool publication
arrow_rightTMC-SNPdb / TMC-SNPdb 2.0: Indian germline variant databases for cancer genome interpretation โ€“ ACTREC
arrow_rightBreast cancer endocrine therapy resistance mechanisms: progesterone biology and genomic drivers โ€“ Dutt Lab research
Awards & Academic Recognition
arrow_rightShanti Swarup Bhatnagar Prize for Science and Technology โ€“ Medical Sciences โ€“ 2017
arrow_rightTata Innovation Fellowship Award, Department of Biotechnology, Government of India โ€“ 2023
arrow_rightTop 75 Scientists Shaping India's Future, Department of Science and Technology โ€“ 2022
arrow_rightRamalingaswami Fellowship Award, Department of Biotechnology, Government of India โ€“ 2010
arrow_rightWellcome Trust / DBT India Alliance Intermediate Fellowship โ€“ 2011
arrow_rightSwiss National Science Foundation Postdoctoral Fellowship โ€“ 2005
Editorial & Academic Roles
arrow_rightFaculty Member โ€“ Medical Genetics, F1000 Prime
arrow_rightEditorial Board Member โ€“ PLOS ONE
arrow_rightEditorial Board Member โ€“ BMC Genomics
arrow_rightMember of scientific advisory and expert committees for government and research organisations
11,500+ Citations | h-index 41

Dr. Dutt's research has garnered over 11,500 citations with an h-index of 41, reflecting his global impact in cancer genomics and precision oncology.

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Education & Training

Dr. Dutt holds dual doctoral degrees from ICGEB / Jamia Millia Islamia and the University of Zurich, with postdoctoral training at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute.

Undergraduate
BSc (Life Sciences)
University of Delhi
1991 โ€“ 1994
Diploma
Diploma (Life Sciences / Biotechnology)
Sri Venkateswara College, University of Delhi
1994 โ€“ 1995
Postgraduate
MSc (Biotechnology / Plant Genetics)
Jamia Millia Islamia, New Delhi
1995 โ€“ 1997
Doctoral
PhD (Plant Genetics)
ICGEB (International Centre for Genetic Engineering and Biotechnology), New Delhi
1997 โ€“ 2000
Doctoral
PhD (Developmental Biology)
University of Zurich, Switzerland
2000 โ€“ 2004
Postdoctoral
Postdoctoral Fellow โ€“ Prion Biology
University Hospital Zurich, Switzerland
2004 โ€“ 2005
Postdoctoral
Postdoctoral Fellow โ€“ Cancer Genomics
Broad Institute of MIT and Harvard / Dana-Farber Cancer Institute, Boston, USA
2005 โ€“ 2010
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Clinical Experience

Dr. Dutt has over 20 years of research experience spanning postdoctoral work at leading global institutions and independent PI-level research in India, culminating in his appointment as Professor at University of Delhi South Campus in 2024.

Professor and Tata Innovation Fellow
University of Delhi South Campus
Department of Genetics
check_circleIntegrated Cancer Genomics โ€“ Dutt Lab
check_circlePrecision Oncology Research & Biomarker Discovery
check_circleNext-Generation Sequencing & Computational Biology
check_circleFormer Principal Investigator / Scientific Officer G โ€“ ACTREC, Tata Memorial Centre (2010โ€“2024)
check_circlePostdoctoral Research โ€“ Broad Institute of MIT & Harvard / Dana-Farber
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Languages & International

Dr. Dutt consults and communicates in the following languages.

๐Ÿ‡ฌ๐Ÿ‡งEnglish
๐Ÿ‡ฎ๐Ÿ‡ณHindi
Interpreter Support Available

CancerFax can coordinate professional medical interpreter support for international patients engaging with Dr. Dutt's research team or associated institutions.

CancerFax can coordinate professional medical interpreter support for international patients where required.

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How CancerFax Helps You Access Dr. Amit Dutt

CancerFax is a specialist cancer patient-navigation platform. We help international patients prepare structured medical summaries, assess treatment eligibility, and connect directly with Dr. Amit Dutt's team โ€” with full coordination from initial inquiry to consultation.

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Medical Report Review

Free review of your pathology results, imaging, molecular profiling, and treatment history โ€” prepared as a structured clinical summary for Dr. Amit Dutt's team.

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Treatment Eligibility Screening

CancerFax screens your case for eligibility for treatments and clinical programmes available through Dr. Amit Dutt before you travel, so you arrive with a clear pathway.

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Case Submission

We coordinate direct case submission to Dr. Amit Dutt's department, including all documentation required for clinical review and appointment scheduling.

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Appointment & Consultation Coordination

CancerFax manages appointment scheduling with Dr. Amit Dutt's team, confirming availability and aligning timelines with your travel plans.

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Travel, Visa & Logistics Support

We prepare visa invitation letters, provide hospital-proximity accommodation guidance, and coordinate airport transfers for international patients.

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Follow-Up & Continuity of Care

After your consultation or treatment, CancerFax facilitates communication between Dr. Amit Dutt's team and your home oncologist for seamless post-treatment follow-up.

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Frequently Asked Questions About Dr. Amit Dutt

Dr. Amit Dutt is a PhD cancer genomics scientist and Professor at the Department of Genetics, University of Delhi South Campus, and a Tata Innovation Fellow. He is best known for his research in integrated cancer genomics, precision oncology, next-generation sequencing, and cancer biomarker discovery. He is a recipient of the Shanti Swarup Bhatnagar Prize for Medical Sciences โ€” India's highest science honour.

Dr. Amit Dutt is a PhD research scientist, not a treating clinical oncologist. He is profiled on CancerFax as a cancer genomics and precision oncology expert whose research contributes to molecular diagnostics, biomarker identification, and targeted therapy frameworks. Patients requiring clinical treatment should work with a qualified treating oncologist, who may draw on genomic research such as Dr. Dutt's for precision therapy guidance.

Dr. Dutt's laboratory has worked on lung cancer, breast cancer, oral and head and neck cancer, cervical cancer, gallbladder cancer, and other cancers prevalent in India. His research focuses on identifying somatic genetic alterations, oncogenic drivers, therapeutic vulnerabilities, and clinically relevant biomarkers across these cancer types.

Dr. Dutt is best known for cancer genomics research โ€” particularly the characterisation and functional validation of somatic alterations in Indian cancer patient cohorts. He received the Shanti Swarup Bhatnagar Prize in 2017 for work translating genomic discoveries into clinical insights. He is also known for developing HPVDetector (an NGS-based HPV genome detection tool) and the TMC-SNPdb Indian germline variant database, which support cancer genome interpretation.

Modern cancer care increasingly relies on molecular profiling to guide targeted and precision therapy. Dr. Dutt's genomic research provides the foundational data underpinning decisions such as whether a patient's tumour carries an EGFR mutation suitable for TKI therapy, or whether a breast cancer is driven by hormonal resistance pathways. CancerFax can help patients and care teams understand how precision oncology and NGS testing may be relevant to their case.

A direct individual international consultation service for Dr. Dutt was not verified through public sources. International patients seeking oncology consultations at ACTREC, Tata Memorial Centre or its affiliated institutions may use the official ACTREC international patient services channel. CancerFax can support medical report preparation, case coordination, and referral to appropriate clinical teams at Tata Memorial Centre, subject to institutional availability.

Submit your medical reports and any existing molecular profiling results through CancerFax using the 'Send Your Reports' button. The CancerFax team will review the documents, prepare a structured case summary, and coordinate the next steps with the relevant clinical or research team, subject to institutional availability and case acceptance.

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Medical Disclaimer: Information on this page is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making any medical decisions.

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